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[抗结核药物性肝损伤新型生物标志物的研究进展]

[Progress in novel biomarkers of anti-tuberculosis drug-induced liver injury].

作者信息

Wang L L, Liu S T, Tang S J, Li P B

机构信息

Tuberculosis Research Units, Chongqing Public Health Medical Center, Chongqing 400036, China.

Chongqing Public Health Medical Center, Chongqing 400036, China.

出版信息

Zhonghua Jie He He Hu Xi Za Zhi. 2024 May 12;47(5):469-474. doi: 10.3760/cma.j.cn112147-20230915-00161.

Abstract

Anti-tuberculosis drug-induced liver injury(ATB-DILI) is the most common adverse reaction during anti-tuberculosis therapy in tuberculosis patients. At present, the diagnosis of ATB-DILI is mainly based on traditional biomarkers such as transaminases, but these indicators have low specificity for liver toxicity, they cannot explain the mechanism of liver injury and the early onset of ATB-DILI. Based on the prediction of disease severity, treatment and prevention, this paper described the current potential biomarkers of ATB-DILI.

摘要

抗结核药物性肝损伤(ATB-DILI)是结核病患者抗结核治疗过程中最常见的不良反应。目前,ATB-DILI的诊断主要基于转氨酶等传统生物标志物,但这些指标对肝毒性的特异性较低,无法解释肝损伤机制及ATB-DILI的早期发病情况。基于对疾病严重程度、治疗及预防的预测,本文阐述了目前ATB-DILI潜在的生物标志物。

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