Department of Neurosurgery, The Affiliated Taian City Central Hospital of Qingdao University, Tai'an City, Shandong, 271000, People's Republic of China.
Department of Gynecology, The Affiliated Taian City Central Hospital of Qingdao University, Tai'an City, Shandong, 271000, People's Republic of China.
Drug Des Devel Ther. 2024 Apr 29;18:1399-1414. doi: 10.2147/DDDT.S463177. eCollection 2024.
Hydrogen, which is a novel biomedical molecule, is currently the subject of extensive research involving animal experiments and in vitro cell experiments, and it is gradually being applied in clinical settings. Hydrogen has been proven to possess anti-inflammatory, selective antioxidant, and antiapoptotic effects, thus exhibiting considerable protective effects in various diseases. In recent years, several studies have provided preliminary evidence for the protective effects of hydrogen on spinal cord injury (SCI). This paper provides a comprehensive review of the potential molecular biology mechanisms of hydrogen therapy and its application in treating SCI, with an aim to better explore the medical value of hydrogen and provide new avenues for the adjuvant treatment of SCI.
氢气是一种新型的生物医学分子,目前正广泛应用于动物实验和体外细胞实验,并且逐渐应用于临床环境。已证明氢气具有抗炎、选择性抗氧化和抗凋亡作用,因此在各种疾病中具有相当大的保护作用。近年来,有几项研究为氢气对脊髓损伤(SCI)的保护作用提供了初步证据。本文全面综述了氢气治疗的潜在分子生物学机制及其在治疗 SCI 中的应用,旨在更好地探索氢气的医学价值,为 SCI 的辅助治疗提供新途径。