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降低精神卫生保健中的自杀率:荷兰一项为期4年的随访实施研究(SUPRANET)的结果

Reducing suicides in mental healthcare: results from a 4-year follow-up implementation study in the Netherlands (SUPRANET).

作者信息

Setkowski Kim, van Balkom Anton J L M, Hoogendoorn Adriaan W, Franx Gerdien, Veerbeek Marjolein, de Winter Remco F P, Gilissen Renske

机构信息

Research Department, 113 Suicide Prevention, Amsterdam, Netherlands.

Amsterdam University Medical Center (UMC), location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Public Health Research Institute and GGZ inGeest (Mental Health Institution), Amsterdam, Netherlands.

出版信息

Front Psychiatry. 2024 Apr 19;15:1080235. doi: 10.3389/fpsyt.2024.1080235. eCollection 2024.

Abstract

OBJECTIVE

In 2016, the SUicide PRevention Action NETwork (SUPRANET) was launched. The SUPRANET intervention aims at better implementing the suicide prevention guideline. An implementation study was developed to evaluate the impact of SUPRANET over time on three outcomes: 1) suicides, 2) registration of suicide attempts, and 3) professionals' knowledge and adherence to the guideline.

METHODS

This study included 13 institutions, and used an uncontrolled longitudinal prospective design, collecting biannual data on a 2-level structure (institutional and team level). Suicides and suicide attempts were extracted from data systems. Professionals' knowledge and adherence were measured using a self-report questionnaire. A three-step interrupted time series analysis (ITSA) was performed for the first two outcomes. Step 1 assessed whether institutions executed the SUPRANET intervention as intended. Step 2 examined if institutions complied with the four guideline recommendations. Based on steps 1 and 2, institutions were classified as below or above average and after that, included as moderators in step 3 to examine the effect of SUPRANET over time compared to the baseline. The third outcome was analyzed with a longitudinal multilevel regression analysis, and tested for moderation.

RESULTS

After institutions were labeled based on their efforts and investments made (below average vs above average), we found no statistically significant difference in suicides (standardized mortality ratio) between the two groups relative to the baseline. Institutions labeled as above average did register significantly more suicide attempts directly after the start of the intervention (78.8 per 100,000 patients, <0.001, 95%CI=(51.3 per 100,000, 106.4 per 100,000)), and as the study progressed, they continued to report a significantly greater improvement in the number of registered attempts compared with institutions assigned as below average (8.7 per 100,000 patients per half year, =0.004, 95%CI=(3.3 per 100,000, 14.1 per 100,000)). Professionals working at institutions that invested more in the SUPRANET activities adhered significantly better to the guideline over time (b=1.39, 95%CI=(0.12,2.65), =0.032).

CONCLUSION

Institutions labeled as above average registered significantly more suicide attempts and also better adhered to the guideline compared with institutions that had performed less well. Although no convincing intervention effect on suicides was found within the study period, we do think that this network is potentially able to reduce suicides. Continuous investments and fully implementing as many guideline recommendations as possible are essential to achieve the biggest drop in suicides.

摘要

目的

2016年,自杀预防行动网络(SUPRANET)启动。SUPRANET干预旨在更好地实施自杀预防指南。开展了一项实施研究,以评估SUPRANET随时间推移对三个结果的影响:1)自杀;2)自杀未遂登记;3)专业人员对指南的知识掌握情况和遵循程度。

方法

本研究纳入了13家机构,采用无对照纵向前瞻性设计,在两级结构(机构和团队层面)上每半年收集一次数据。自杀和自杀未遂情况从数据系统中提取。专业人员的知识掌握情况和遵循程度通过自我报告问卷进行测量。对前两个结果进行了三步中断时间序列分析(ITSA)。第一步评估机构是否按预期实施了SUPRANET干预。第二步检查机构是否遵守了四项指南建议。根据第一步和第二步,将机构分为低于平均水平或高于平均水平,然后在第三步中将其作为调节变量纳入,以检验SUPRANET相对于基线随时间的效果。对第三个结果进行纵向多水平回归分析,并进行调节检验。

结果

根据机构的努力和投入(低于平均水平与高于平均水平)进行分类后,我们发现两组相对于基线的自杀情况(标准化死亡率)在统计学上无显著差异。被标记为高于平均水平的机构在干预开始后直接登记的自杀未遂显著更多(每10万人中有78.8例,<0.001,95%置信区间=(每10万人中有51.3例,每10万人中有106.4例)),并且随着研究的推进,与被归类为低于平均水平的机构相比,它们报告的登记未遂数量持续显著改善(每半年每10万人中有8.7例,=0.004, 95%置信区间=(每10万人中有3.3例,每10万人中有14.1例))。随着时间的推移,在SUPRANET活动中投入更多的机构中的专业人员对指南的遵循程度显著更高(b = 1.39,95%置信区间=(0.12, 2.65),= 0.032)。

结论

与表现较差的机构相比,被标记为高于平均水平 的机构登记的自杀未遂显著更多,并且对指南的遵循程度也更好。尽管在研究期间未发现对自杀有令人信服的干预效果,但我们确实认为这个网络有可能减少自杀。持续投入并尽可能全面地实施指南建议对于实现自杀率的最大降幅至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddcf/11068092/4bbc94503ab2/fpsyt-15-1080235-g001.jpg

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