Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, Virginia, USA.
Department of Kinesiology, University of Texas at Arlington, Arlington, Texas, USA.
Exp Physiol. 2024 Jun;109(6):992-1003. doi: 10.1113/EP091762. Epub 2024 May 6.
Young individuals with post-traumatic stress disorder (PTSD) display peripheral vascular and autonomic nervous system dysfunction, two factors potentially stemming from a redox imbalance. It is currently unclear if these aforementioned factors, observed at rest, alter peripheral haemodynamic responses to exercise in this population. This study examined haemodynamic responses to handgrip exercise in young individuals with PTSD following acute antioxidant (AO) supplementation. Thirteen young individuals with PTSD (age 23 ± 3 years), and 13 age- and sex-matched controls (CTRL) participated in the study. Exercise-induced changes to arm blood flow (BF), mean arterial pressure (MAP) and vascular conductance (VC) were evaluated across two workloads of rhythmic handgrip exercise (3 and 6 kg). The PTSD group participated in two visits, consuming either a placebo (PL) or AO prior to their visits. The PTSD group demonstrated significantly lower VC (P = 0.04) across all exercise workloads (vs. CTRL), which was significantly improved following AO supplementation. In the PTSD group, AO supplementation improved VC in participants possessing the lowest VC responses to handgrip exercise, with AO supplementation significantly improving VC responses (3 and 6 kg: P < 0.01) by blunting elevated exercise-induced MAP responses (3 kg: P = 0.01; 6 kg: P < 0.01). Lower VC responses during handgrip exercise were improved following AO supplementation in young individuals with PTSD. AO supplementation was associated with a blunting of exercise-induced MAP responses in individuals with PTSD displaying elevated MAP responses. This study revealed that young individuals with PTSD exhibit abnormal, peripherally mediated exercise responses that may be linked to a redox imbalance.
患有创伤后应激障碍（PTSD）的年轻人表现出外周血管和自主神经系统功能障碍，这两个因素可能源于氧化还原失衡。目前尚不清楚这些在休息时观察到的因素是否会改变该人群在运动时的外周血液动力学反应。本研究在急性抗氧化（AO）补充后检查了 PTSD 年轻人的手握运动后的血液动力学反应。13 名患有 PTSD（年龄 23 ± 3 岁）的年轻人和 13 名年龄和性别匹配的对照组（CTRL）参加了研究。评估了两种节律性手握运动（3 和 6 kg）负荷下手臂血流量（BF）、平均动脉压（MAP）和血管传导性（VC）的运动诱导变化。PTSD 组在两次就诊时分别服用安慰剂（PL）或 AO。与对照组相比，PTSD 组在所有运动负荷下的 VC 均显著降低（P = 0.04），AO 补充后明显改善。在 PTSD 组中，AO 补充改善了 VC 最低的手握运动反应的参与者的 VC，AO 补充通过削弱升高的运动诱导的 MAP 反应显著改善 VC 反应（3 和 6 kg：P < 0.01）（3 kg：P = 0.01；6 kg：P < 0.01）。PTSD 年轻人手握运动时的 VC 反应在 AO 补充后得到改善。AO 补充与 PTSD 中 MAP 反应升高的个体的 MAP 诱导反应的减弱相关。本研究表明，患有 PTSD 的年轻人表现出异常的、外周介导的运动反应，这可能与氧化还原失衡有关。
