Abdel-Qader Derar H, Albassam Abdullah, Taybeh Esra', Al Mazrouei Nadia, Meer Sara Murad Albarkat, Al-Kubaisi Khalid Awad, Ibrahim Rana, Elnour Asim Ahmed, Mohamed Ibrahim Osama, AbuRuz Salah
Faculty of Pharmacy & Medical Sciences, University of Petra, Amman 11196, Jordan.
Department of Pharmacy Practice, Faculty of Pharmacy, Kuwait University, Kuwait 12037, Kuwait.
J Clin Med. 2024 Apr 24;13(9):2499. doi: 10.3390/jcm13092499.
: Schizophrenia, unipolar depression, bipolar disorder, bipolar mania, and bipolar depression are a few of the severe psychiatric diseases that affect millions of individuals and their overall life quality. This study aimed to look at differences in TGA, TC, HDL, LDL, and FPG levels in people who were going through acute episodes of listed diseases. : A cross-sectional prospective study was carried out in Jordan between January and November of 2023, involving all patients with the aforementioned diseases who attended three psychiatric clinics. This study encompassed results from 1187 patients (women N = 675, 56.87%) who were classified into the following ranges: <25, 25-45, 45-65, and >65. : The average level of LDL was the highest in bipolar depression (112.442 ± 36.178 mg/dL) and the lowest in bipolar mania (111.25 ± 33.14 mg/dL). The average level of HDL was the highest in schizophrenia (58.755 ± 16.198 mg/dL) and the lowest in bipolar depression (45.584 ± 12.128 mg/dL). Both average levels of TC and TGA were the highest in patients with bipolar depression (188.403 ± 37.396 mg/dL and 149.685 ± 96.951 mg/dL, respectively) and the lowest in bipolar mania (164.790 ± 40.488 mg/dL and 100.679 ± 54.337 mg/dL, respectively). The average level of FPG was the highest in unipolar depression (94.00 ± 21.453 mg/dL) and the lowest in bipolar mania (89.492 ± 14.700 mg/dL). : The results confirmed that lipid and glucose abnormalities were more common in people with schizophrenia and mood disorders (unipolar and bipolar).
精神分裂症、单相抑郁症、双相情感障碍、双相躁狂症和双相抑郁症是影响数百万人及其整体生活质量的几种严重精神疾病。本研究旨在观察患有上述疾病急性发作的人群中甘油三酯(TGA)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)和空腹血糖(FPG)水平的差异。:2023年1月至11月在约旦进行了一项横断面前瞻性研究,纳入了所有前往三家精神科诊所就诊的上述疾病患者。本研究涵盖了1187名患者的结果(女性N = 675,占56.87%),这些患者被分为以下年龄段:<25岁、25 - 45岁、45 - 65岁和>65岁。:低密度脂蛋白的平均水平在双相抑郁症中最高(112.442±36.178毫克/分升),在双相躁狂症中最低(111.25±33.14毫克/分升)。高密度脂蛋白的平均水平在精神分裂症中最高(58.755±16.198毫克/分升),在双相抑郁症中最低(45.584±12.128毫克/分升)。总胆固醇和甘油三酯的平均水平在双相抑郁症患者中均最高(分别为188.403±37.396毫克/分升和149.685±96.951毫克/分升),在双相躁狂症中最低(分别为164.790±40.488毫克/分升和100.679±54.337毫克/分升)。空腹血糖的平均水平在单相抑郁症中最高(94.00±21.453毫克/分升),在双相躁狂症中最低(89.492±14.700毫克/分升)。:结果证实,脂质和葡萄糖异常在精神分裂症和情绪障碍(单相和双相)患者中更为常见。