Zalaquett Nader G, Salameh Elio, Kim Jonathan M, Ghanbarian Elham, Tawk Karen, Abouzari Mehdi
Faculty of Medicine, American University of Beirut, Beirut 1107, Lebanon.
Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA 92697, USA.
J Clin Med. 2024 May 4;13(9):2701. doi: 10.3390/jcm13092701.
Migraine is a prevalent episodic brain disorder known for recurrent attacks of unilateral headaches, accompanied by complaints of photophobia, phonophobia, nausea, and vomiting. Two main categories of migraine are migraine with aura (MA) and migraine without aura (MO). Early twin and population studies have shown a genetic basis for these disorders, and efforts have been invested since to discern the genes involved. Many techniques, including candidate-gene association studies, loci linkage studies, genome-wide association, and transcription studies, have been used for this goal. As a result, several genes were pinned with concurrent and conflicting data among studies. It is important to understand the evolution of techniques and their findings. This review provides a chronological understanding of the different techniques used from the dawn of migraine genetic investigations and the genes linked with the migraine subtypes.
偏头痛是一种常见的发作性脑部疾病，以单侧头痛反复发作并伴有畏光、畏声、恶心和呕吐等症状为特征。偏头痛主要分为有先兆偏头痛（MA）和无先兆偏头痛（MO）两类。早期的双胞胎和人群研究表明这些疾病存在遗传基础，此后人们一直在努力识别其中涉及的基因。许多技术，包括候选基因关联研究、基因座连锁研究、全基因组关联研究和转录研究，都被用于这一目标。结果，多项研究中确定了几个基因，但数据存在同时出现和相互矛盾的情况。了解技术的发展及其研究结果很重要。这篇综述按时间顺序介绍了偏头痛基因研究初期所使用的不同技术以及与偏头痛亚型相关的基因。
