在温和条件下以Pt/C为催化剂合成全氘代烷基胺/酰胺。
Synthesis of Perdeuterated Alkyl Amines/Amides with Pt/C as Catalyst under Mild Conditions.
作者信息
Zhang Hong-Hai, Chen Meng-Zhe, Yu Xinbin, Bonnesen Peter V, Wu Zili, Chen Hsin-Lung, O'Neill Hugh
机构信息
Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.
Department of Chemical Engineering, National Tsing Hua University, Hsinchu 300044, Taiwan.
出版信息
J Org Chem. 2024 Jun 7;89(11):8262-8266. doi: 10.1021/acs.joc.4c00553. Epub 2024 May 13.
A convenient method for the synthesis of perdeuterated alkyl amides/amines is disclosed. Perdeuterated acetyl amides can be achieved by a hydrogen-deuterium (H/D) exchange protocol with Pt/C as a catalyst and DO as a deuterium source under mild conditions. After removal or reduction of the acetyl group, this protocol can provide perdeuterated primary, secondary, and tertiary amines, which are difficult to achieve via other methods.
公开了一种合成全氘代烷基酰胺/胺的简便方法。在温和条件下，以Pt/C为催化剂、DO为氘源，通过氢-氘（H/D）交换协议可实现全氘代乙酰酰胺。除去或还原乙酰基后，该协议可提供全氘代伯胺、仲胺和叔胺，而这些通过其他方法难以实现。
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