Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Dong Road, Erqi District, Zhengzhou 450052, China.
Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin 300052, China.
Cereb Cortex. 2024 May 2;34(5). doi: 10.1093/cercor/bhae182.
This study investigates abnormalities in cerebellar-cerebral static and dynamic functional connectivity among patients with acute pontine infarction, examining the relationship between these connectivity changes and behavioral dysfunction. Resting-state functional magnetic resonance imaging was utilized to collect data from 45 patients within seven days post-pontine infarction and 34 normal controls. Seed-based static and dynamic functional connectivity analyses identified divergences in cerebellar-cerebral connectivity features between pontine infarction patients and normal controls. Correlations between abnormal functional connectivity features and behavioral scores were explored. Compared to normal controls, left pontine infarction patients exhibited significantly increased static functional connectivity within the executive, affective-limbic, and motor networks. Conversely, right pontine infarction patients demonstrated decreased static functional connectivity in the executive, affective-limbic, and default mode networks, alongside an increase in the executive and motor networks. Decreased temporal variability of dynamic functional connectivity was observed in the executive and default mode networks among left pontine infarction patients. Furthermore, abnormalities in static and dynamic functional connectivity within the executive network correlated with motor and working memory performance in patients. These findings suggest that alterations in cerebellar-cerebral static and dynamic functional connectivity could underpin the behavioral dysfunctions observed in acute pontine infarction patients.
本研究旨在探讨急性脑桥梗死患者小脑-大脑静息和动态功能连接的异常，考察这些连接变化与行为功能障碍之间的关系。研究采用静息态功能磁共振成像技术，在脑桥梗死后 7 天内收集了 45 名患者和 34 名正常对照者的数据。基于种子的静息态和动态功能连接分析发现，脑桥梗死患者与正常对照者小脑-大脑连接特征存在差异。探讨了异常功能连接特征与行为评分之间的相关性。与正常对照组相比，左侧脑桥梗死患者的执行、情感-边缘和运动网络内的静息态功能连接明显增加。相反，右侧脑桥梗死患者的执行、情感-边缘和默认模式网络内的静息态功能连接减少，同时执行和运动网络内的静息态功能连接增加。左侧脑桥梗死患者的执行和默认模式网络内的动态功能连接的时间变异性降低。此外，执行网络内的静息态和动态功能连接异常与患者的运动和工作记忆表现相关。这些发现表明小脑-大脑静息态和动态功能连接的改变可能是急性脑桥梗死患者观察到的行为功能障碍的基础。
