Zhou Jing, Li Mingxing, Liao Ling
Department of Ultrasound, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
Department of Ultrasound Medicine, West China Hospital, Sichuan University, Chengdu, 610044, China.
BJR Case Rep. 2024 Apr 25;10(3):uaae013. doi: 10.1093/bjrcr/uaae013. eCollection 2024 May.
T-cell lymphoblastic lymphoma of the breast represents a highly uncommon subtype of non-Hodgkin's lymphoma. This study presents a case of T-cell lymphoblastic lymphoma/acute lymphoblastic leukaemia (T-LBL/ALL) in a 73-year-old female patient exhibiting bilateral breast masses, bilateral axillary lymphadenopathy, swollen lymph nodes in the left neck, and petechiae on the chest. The breast ultrasound revealed heterogeneous hypoechoic findings in the skin layer and subcutaneous tissue of the upper outer quadrant of both breasts. Contrast-enhanced ultrasound (CEUS) demonstrated rapid homogeneous hyperenhancement of bilateral breast masses, and with a small unenhanced area noted in the centre of the left breast mass. The fine-needle aspiration cytology (FNAC) of bilateral axillary lymph nodes revealed metastatic adenocarcinoma, whereas the FNAC of the left cervical lymph nodes indicated non-Hodgkin's lymphoma. Biopsy of the breast mass demonstrated multifocal growth of lymphocyte-like cells, with immunohistochemical analysis confirming T-LBL/ALL. This case study outlines the clinical and CEUS features of breast T-LBL/ALL.
乳腺T细胞淋巴母细胞淋巴瘤是一种非常罕见的非霍奇金淋巴瘤亚型。本研究报告了一例73岁女性患者的T细胞淋巴母细胞淋巴瘤/急性淋巴细胞白血病(T-LBL/ALL),该患者表现为双侧乳腺肿块、双侧腋窝淋巴结肿大、左侧颈部淋巴结肿大以及胸部瘀点。乳腺超声显示双侧乳腺外上象限皮肤层和皮下组织有不均匀低回声表现。超声造影(CEUS)显示双侧乳腺肿块快速均匀性高增强,左侧乳腺肿块中心可见一小片无增强区。双侧腋窝淋巴结细针穿刺细胞学检查(FNAC)显示转移性腺癌,而左侧颈部淋巴结FNAC提示非霍奇金淋巴瘤。乳腺肿块活检显示淋巴细胞样细胞多灶性生长,免疫组化分析证实为T-LBL/ALL。本病例研究概述了乳腺T-LBL/ALL的临床和CEUS特征。