糖化血红蛋白短期变化与 2 型糖尿病患者身体成分的关系及肌肉维持的重要性。
Association of short-term changes in HbA1c with body composition and the importance of muscle maintenance in patients with Type 2 diabetes.
机构信息
Matsuda Diabetes Clinic, Kobe, Japan; Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan; Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Division of Health Sciences, Department of Public Health, Kobe University Graduate School of Health Sciences, Kobe, Japan; School of Nursing, Kobe City College of Nursing, Kobe, Japan.
出版信息
J Diabetes Complications. 2024 Jun;38(6):108746. doi: 10.1016/j.jdiacomp.2024.108746. Epub 2024 Apr 18.
AIMS
This study aimed to investigate the relationship between changes in glucose metabolism and body composition in patients with diabetes.
METHODS
We included 380 patients with type 2 diabetes, who underwent bioelectrical impedance analysis, in this longitudinal study. Changes in HbA1c (ΔHbA1c) levels and body composition indices were compared between baseline and 6 months. A multivariate analysis was performed to examine the relationship between ΔHbA1c and changes in body composition.
RESULTS
HbA1c levels were significantly decreased at 6 months (P < 0.01), but there was no significant change in BMI. A linear multiple regression analysis showed that ΔHbA1c was negatively correlated with changes in muscle mass (β = -0.18; P = 0.047) and bone mineral content (β = -0.28; P < 0.001), but there was no significant association between ΔHbA1c levels and a change in body fat percentage.
CONCLUSIONS
This study shows a limited association between short-term changes in glucose metabolism and changes in body composition in patients with type 2 diabetes. Therefore, interventions aimed at reducing adiposity may not affect glucose metabolism in the short term, while interventions focused on maintaining or enhancing muscle mass and bone mineral content may play an important role in diabetes management.
目的
本研究旨在探讨糖尿病患者血糖代谢变化与身体成分之间的关系。
方法
我们纳入了 380 例 2 型糖尿病患者进行这项纵向研究，所有患者均接受了生物电阻抗分析。比较了基线和 6 个月时的糖化血红蛋白（HbA1c）水平变化（ΔHbA1c）和身体成分指数的变化。采用多元分析来检查ΔHbA1c 与身体成分变化之间的关系。
结果
HbA1c 水平在 6 个月时显著下降（P<0.01），但 BMI 无明显变化。线性多元回归分析显示，ΔHbA1c 与肌肉量的变化呈负相关（β=-0.18；P=0.047），与骨矿物质含量的变化呈负相关（β=-0.28；P<0.001），但与体脂百分比的变化无显著相关性。
结论
本研究表明，2 型糖尿病患者血糖代谢的短期变化与身体成分的变化之间仅有有限的关联。因此，旨在减少脂肪量的干预措施可能不会在短期内影响血糖代谢，而专注于维持或增强肌肉量和骨矿物质含量的干预措施可能在糖尿病管理中发挥重要作用。
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