AS03 佐剂免疫：天然优势。
Immunity by AS03ation: The natural adjuvantage.
机构信息
Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
出版信息
Immunity. 2024 May 14;57(5):927-929. doi: 10.1016/j.immuni.2024.04.011.
Humans do not respond equally to vaccination. To investigate why, Mulè et al. developed a multimodal framework and found that high responders after unadjuvanted influenza vaccination exist in a naturally adjuvanted state, mimicking innate immunophenotypes following AS03-adjuvanted vaccination. This highlights biological factors that set apart high-antibody responders and how adjuvants can boost innate immune cues to improve humoral immunity.
人类对疫苗接种的反应并不相同。为了探究原因，Mulè 等人开发了一种多模态框架，发现未佐剂流感疫苗接种后的高反应者存在自然佐剂状态，类似于 AS03 佐剂疫苗接种后的固有免疫表型。这突出了区分高抗体应答者的生物学因素，以及佐剂如何增强固有免疫信号以改善体液免疫。
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