大逃亡：志贺氏菌效应物解锁隔膜栓。

The great escape: a Shigella effector unlocks the septin cage.

机构信息

Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK.

出版信息

Nat Commun. 2024 May 15;15(1):4104. doi: 10.1038/s41467-024-48208-1.

DOI:10.1038/s41467-024-48208-1

PMID:38750009

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11096336/

Abstract

, an important human pathogen, can secrete effector proteins to invade host cells and evade mechanisms of cell-autonomous immunity. In a new manuscript published in , Xian et al. report that the kinase effector OspG promotes the ubiquitination of septin cytoskeletal proteins to evade cage entrapment.

摘要

淋病奈瑟菌，一种重要的人类病原体，能够分泌效应蛋白来入侵宿主细胞并逃避细胞自主免疫机制。在一项发表于的新研究中，冼等人报告称，激酶效应物 OspG 促进了 septin 细胞骨架蛋白的泛素化，从而逃避了牢笼捕获。