超越抑郁：处于阿尔茨海默病风险中的老年女性全谱情绪症状与tau病理相关。
Moving Beyond Depression: Mood Symptoms Across the Spectrum Relate to Tau Pathology in Older Women at Risk for Alzheimer's Disease.
作者信息
Ahmadi Nargis, Dratva Melanie A, Heyworth Nadine, Wang Xin, Blennow Kaj, Banks Sarah J, Sudermann Erin E
机构信息
University of California, San Diego, USA.
Department of Neurosciences, University of California, San Diego, USA.
出版信息
Int J Aging Hum Dev. 2025 Jan;100(1):3-22. doi: 10.1177/00914150241253257. Epub 2024 May 15.
We examined how symptoms across the mood spectrum relate to Alzheimer's disease (AD) biomarkers in older women at high risk for AD. Participants included 25 women aged 65+ with mild cognitive deficits and elevated AD genetic risk. The Profile of Mood States Questionnaire measured mood symptoms and a total mood disturbance (TMD) score. Tau burden in the meta-temporal region of interest was measured using MK-6240 Tau positron emission tomography (PET) imaging. A subset ( = 12) also had p-Tau181, and Aß40/42 levels measured in plasma. Higher TMD scores related to higher tau PET standardized uptake value ratio (SUVR). Greater negative mood symptoms correlated with higher tau PET SUVR, while greater vigor correlated with lower SUVR. Similar results were seen with plasma p-Tau181 levels, but not with Aβ40/42 levels. In conclusion, positive and negative mood symptoms related to tau pathology in older women at high risk for AD, highlighting a role of mental well-being in AD risk.
我们研究了处于患阿尔茨海默病（AD）高风险的老年女性中，整个情绪谱上的症状与AD生物标志物之间的关系。参与者包括25名65岁及以上、有轻度认知缺陷且AD遗传风险升高的女性。情绪状态问卷测量了情绪症状和总情绪紊乱（TMD）得分。使用MK-6240 Tau正电子发射断层扫描（PET）成像测量颞叶感兴趣区的Tau负荷。一个子集（n = 12）还检测了血浆中的p-Tau181和Aβ40/42水平。较高的TMD得分与较高的Tau PET标准化摄取值比率（SUVR）相关。更大的负面情绪症状与较高的Tau PET SUVR相关，而更大的活力与较低的SUVR相关。血浆p-Tau181水平也有类似结果，但Aβ40/42水平则不然。总之，处于AD高风险的老年女性中，正负情绪症状与Tau病理相关，突出了心理健康在AD风险中的作用。
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