Peroutka S J, DeLanney L, Irwin I, Ison P J, Ricaurte G, Schlegel J R, Langston J W
Res Commun Chem Pathol Pharmacol. 1985 May;48(2):163-71.
Adult C57 B1 mice were injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) using two dosage regimens. Following a 20 mg/kg/hour X 4 schedule, the number of dopamine D2 receptors labeled by 3H-spiperone was significantly increased at 2 days following the last injection of MPTP (124 +/- 8.0% of control values; p less than 0.025). Scatchard analysis revealed an increase in the number of 3H-spiperone binding sites. No significant difference between the control and MPTP treated animals could be detected in 3H-spiperone binding at 4 and 6 days following the short term MPTP treatment. Similarly, a regimen of 30 mg/kg/day X 10 MPTP caused a transient increase in 3H-spiperone binding to dopamine D2 receptors (1 day: 143 +/- 12%, p less than 0.01; 10 days: 101 +/- 3.7%, p greater than 0.05). These results suggest that MPTP does not produce permanent supersensitivity of dopamine D2 receptors in the mouse.
成年C57 B1小鼠采用两种给药方案注射1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）。按照20mg/kg/小时×4的给药方案，在最后一次注射MPTP后2天，用3H-螺哌隆标记的多巴胺D2受体数量显著增加（为对照值的124±8.0%；p<0.025）。Scatchard分析显示3H-螺哌隆结合位点数量增加。短期MPTP处理后4天和6天，对照动物和MPTP处理动物的3H-螺哌隆结合情况无显著差异。同样，30mg/kg/天×10的MPTP给药方案导致3H-螺哌隆与多巴胺D2受体的结合出现短暂增加（1天：143±12%，p<0.01；10天：101±3.7%，p>0.05）。这些结果表明，MPTP不会使小鼠多巴胺D2受体产生永久性超敏反应。
