Sari Ratna Fathma, Fadilah Fadilah, Maladan Yustinus, Sarassari Rosantia, Safari Dodi
Master's Programme in Biomedical Sciences, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.
Eijkman Research Center for Molecular Biology, National Research and Innovation Agency, Cibinong, Indonesia.
Clin Exp Vaccine Res. 2024 Apr;13(2):91-104. doi: 10.7774/cevr.2024.13.2.91. Epub 2024 Apr 30.
This narrative review describes genomic characteristic, serotyping, immunogenicity, and vaccine development of capsular polysaccharide (CPS). CPS is a primary virulence factor of . The genomic characteristics of CPS, including the role of biosynthetic gene and genetic variation within (capsule polysaccharide) locus which may lead to serotype replacement are still being investigated. One hundred unique serotypes of have been identified through various methods of serotyping using phenotypic and genotypic approach. The advantages and limitations of each method are various, emphasizing the need for accurate and comprehensive serotyping for effective disease surveillance and vaccine targeting. In addition, we elaborate the critical role of CPS in vaccine development by providing an overview of immunogenicity, ongoing research of pneumococcal vaccines, and the impact on disease burden.
本叙述性综述描述了荚膜多糖（CPS）的基因组特征、血清分型、免疫原性和疫苗开发。CPS是……的主要毒力因子。CPS的基因组特征，包括生物合成基因的作用以及（荚膜多糖）位点内可能导致血清型替换的基因变异仍在研究中。通过使用表型和基因型方法的各种血清分型方法，已鉴定出……的100种独特血清型。每种方法的优缺点各不相同，强调了为有效疾病监测和疫苗靶向进行准确和全面血清分型的必要性。此外，我们通过概述免疫原性、肺炎球菌疫苗的正在进行的研究以及对疾病负担的影响，阐述了CPS在疫苗开发中的关键作用。
