Neurovascular Health Laboratory, Program for Pregnancy and Postpartum Health, Women and Children's Health Research Institute, Alberta Diabetes Institute, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Alberta, Canada.
H. T. Coutts Education & Physical Education Library, University of Alberta, Edmonton, Alberta, Canada.
J Appl Physiol (1985). 2024 Aug 1;137(2):429-444. doi: 10.1152/japplphysiol.00060.2024. Epub 2024 May 16.
The purpose of this systematic review and meta-analysis was to examine the effects of exercise training on muscle sympathetic nerve activity (MSNA) in humans. Studies included exercise interventions [randomized controlled trials (RCTs), nonrandomized controlled trials (non-RCTs), or pre-to-post intervention] that reported on adults (≥18 yr) where MSNA was directly assessed using microneurography, and relevant outcomes were assessed [MSNA (total activity, burst frequency, burst incidence, amplitude), heart rate, blood pressure (systolic blood pressure, diastolic blood pressure, or mean blood pressure), and aerobic capacity (maximal or peak oxygen consumption)]. Forty intervention studies ( = 1,253 individuals) were included. RCTs of exercise compared with no exercise illustrated that those randomized to the exercise intervention had a significant reduction in MSNA burst frequency and incidence compared with controls. This reduction in burst frequency was not different between individuals with cardiovascular disease compared with those without. However, the reduction in burst incidence was greater in those with cardiovascular disease [9 RCTs studies, = 234, mean difference (MD) -21.08 bursts/100 hbs; 95% confidence interval (CI) -16.51, -25.66; = 63%] compared with those without (6 RCTs, = 192, MD -10.92 bursts/100 hbs; 95% CI -4.12, -17.73; = 76%). Meta-regression analyses demonstrated a dose-response relationship where individuals with higher burst frequency and incidence preintervention had a greater reduction in values post-intervention. These findings suggest that exercise training reduces muscle sympathetic nerve activity, which may be valuable for improving cardiovascular health. This systematic review and meta-analysis suggests exercise training reduces muscle sympathetic nerve activity (MSNA), which may be valuable for improving cardiovascular health. The reduction in burst incidence was greater among individuals with cardiovascular disease when compared with those without; exercise training may be particularly beneficial for individuals with cardiovascular disease. Meta-regression analyses demonstrated a dose-response relationship, where individuals with higher sympathetic activity preintervention had greater reductions in sympathetic activity post-intervention.
本系统评价和荟萃分析的目的是研究运动训练对人体肌肉交感神经活动（MSNA）的影响。研究包括运动干预[随机对照试验（RCT）、非随机对照试验（非 RCT）或预-后干预]，这些研究报告了成年人（≥18 岁）使用微神经生理学直接评估 MSNA 的情况，以及评估了相关结果[MSNA（总活动、爆发频率、爆发发生率、幅度）、心率、血压（收缩压、舒张压或平均血压）和有氧能力（最大或峰值耗氧量）]。共有 40 项干预研究（=1253 人）被纳入。与不运动相比，RCT 中运动组的 MSNA 爆发频率和发生率显著降低。与对照组相比，患有心血管疾病的个体与不患有心血管疾病的个体之间，爆发频率的降低没有差异。然而，在心血管疾病患者中，爆发发生率的降低更大[9 项 RCT 研究，=234，平均差异（MD）-21.08 次/100 hbs；95%置信区间（CI）-16.51，-25.66；=63%]，而在无心血管疾病患者中，MD 为-10.92 次/100 hbs；95%CI-4.12，-17.73；=76%）。荟萃回归分析表明存在剂量反应关系，即干预前 MSNA 爆发频率和发生率较高的个体，干预后数值降低幅度更大。这些发现表明，运动训练可降低肌肉交感神经活动，这对于改善心血管健康可能是有价值的。本系统评价和荟萃分析表明，运动训练可降低肌肉交感神经活动（MSNA），这对于改善心血管健康可能是有价值的。与无心血管疾病的个体相比，患有心血管疾病的个体 MSNA 爆发发生率的降低更为显著；运动训练可能对心血管疾病患者特别有益。荟萃回归分析表明存在剂量反应关系，即干预前交感神经活动较高的个体，干预后交感神经活动的降低幅度更大。
