Development of natural perfume as potential fungicide candidates: construction and biological evaluation of vanillin analogs bearing the 1,3,4-oxadiazole/1,3-thiazolidin-4-one fragments.

Two series of vanillin derivatives containing 1,3,4-oxadiazole and 1,3-thiazolidin-4-one scaffolds were prepared and evaluated for their antifungal activity. The results revealed that compounds (29.73 μg/ml) and (38.15 μg/ml) displayed excellent inhibitory activity against the spore of . The inhibitory activity of compound (10.53 μg/ml) against the spore of was more than 42-fold that of vanillin. Compound (37.54 μg/ml) showed better antifungal activity against the spore of than positive controls. The cytotoxicity assay confirmed that compounds , , and showed good selectivity and less toxicity to normal mammalian cells.