University of Warwick, School of Engineering, Coventry, UK; Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
IRCCS Synlab SDN, Naples, Italy.
Diabetes Res Clin Pract. 2024 Jun;212:111708. doi: 10.1016/j.diabres.2024.111708. Epub 2024 May 14.
Recent clinical trials and real-world studies highlighted those variations in ECG waveforms and HRV recurrently occurred during hypoglycemic and hyperglycemic events in patients with diabetes. However, while several studies have been carried out for adult age, there is lack of evidence for paediatric patients. The main aim of the study is to identify the correlations of variations in ECG Morphology waveforms with blood glucose levels in a paediatric population.
T1D paediatric patients who use CGM were enrolled. They wear an additional non-invasive wearable device for recording physiological data and respiratory rate. Glucose metrics, ECG parameters and HRV features were collected, and Wilcoxon rank-sum test and Spearman's correlation analysis were used to explore if different levels of blood glucose were associated to ECG morphological changes.
Results showed that hypoglycaemic events in paediatric patients with T1D are strongly associated with variations in ECG morphology and HRV.
Results showed the opportunity of using the ECG as a non-invasive adding instrument to monitor the hypoglycaemic events through the integration of the ECG continuous information with CGM data. This innovative approach represents a promising step forward in diabetes management, offering a more comprehensive and effective means of detecting and responding to critical changes in glucose levels.
最近的临床试验和真实世界研究强调，在糖尿病患者的低血糖和高血糖事件中，心电图波形和心率变异性会反复出现变化。然而，虽然已经针对成人年龄进行了多项研究，但缺乏针对儿科患者的证据。本研究的主要目的是确定心电图形态波形变化与儿科人群血糖水平之间的相关性。
招募使用 CGMS 的 T1D 儿科患者。他们佩戴额外的非侵入性可穿戴设备来记录生理数据和呼吸频率。收集血糖指标、心电图参数和 HRV 特征，并使用 Wilcoxon 秩和检验和 Spearman 相关分析来探讨不同血糖水平是否与心电图形态变化相关。
结果表明，T1D 儿科患者的低血糖事件与心电图形态和 HRV 的变化密切相关。
结果表明，通过将心电图的连续信息与 CGMS 数据相结合，将心电图作为一种非侵入性附加仪器来监测低血糖事件具有可行性。这种创新方法代表了糖尿病管理方面的一个有前途的进展，为检测和应对血糖水平的关键变化提供了更全面、更有效的手段。
