术后甲状腺广泛转移性滤泡状癌的姑息性治疗：病例报告并文献复习。

Palliative treatment of generalized metastatic follicular carcinoma of thyroid after operation: A case report and literature review.

机构信息

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.

Department of Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.

出版信息

Medicine (Baltimore). 2024 May 17;103(20):e38237. doi: 10.1097/MD.0000000000038237.

DOI:10.1097/MD.0000000000038237

PMID:38758843

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11098185/

Abstract

RATIONALE

Follicular carcinoma of thyroid is a rare pathological type of thyroid carcinoma, accounting for 4.5% of the total. At present, the main treatment methods include surgery, iodine therapy, thyroid hormone inhibitors, etc. Targeted drug therapy is very important for distant metastasis and iodine-refractory differentiated thyroid cancer.

PATIENT CONCERNS

This clinical case is a 51-year-old male patient with follicular carcinoma of thyroid.

DIAGNOSES

After 7 years of total thyroidectomy, multiple distant metastasis occurred to bilateral lungs, bones, multiple lymph nodes, etc.

INTERVENTION

After multidisciplinary consultation in the department of oncology, thoracic surgery, nuclear medicine and other departments, he received targeted drug therapy of Lenvatinib.

OUTCOMES

After 3 months, his condition was partially relieved, and his quality of life was significantly improved. After 11 months of treatment, the evaluated efficacy was still in remission.

LESSON

Late metastatic thyroid cancer is faced with dilemma of radioiodine refractory after traditional treatment. This will provide further evidence for therapeutic intervention in similar patients in the future.

摘要