非侵入性脑电刺激调节人类对心理表象的意识感知。

Non-invasive electrical brain stimulation modulates human conscious perception of mental representation.

机构信息

Institute of Brain and Cognitive Engineering, Korea University, Seoul 02841, South Korea; BK21 Four Institute of Precision Public Health, Korea University, Seoul 02841, South Korea.

Institute of Brain and Cognitive Engineering, Korea University, Seoul 02841, South Korea; BK21 Four Institute of Precision Public Health, Korea University, Seoul 02841, South Korea; Department of Brain and Cognitive Engineering, Korea University, Seoul 02841, South Korea.

出版信息

Neuroimage. 2024 Jul 1;294:120647. doi: 10.1016/j.neuroimage.2024.120647. Epub 2024 May 17.

DOI:10.1016/j.neuroimage.2024.120647

PMID:38761552

Abstract

Mental representation is a key concept in cognitive science; nevertheless, its neural foundations remain elusive. We employed non-invasive electrical brain stimulation and functional magnetic resonance imaging to address this. During this process, participants perceived flickering red and green visual stimuli, discerning them either as distinct, non-fused colours or as a mentally generated, fused colour (orange). The application of transcranial alternating current stimulation to the medial prefrontal region (a key node of the default-mode network) suppressed haemodynamic activation in higher-order subthalamic and central executive networks associated with the perception of fused colours. This implies that higher-order thalamocortical and default-mode networks are crucial in humans' conscious perception of mental representation.

摘要

心理表象是认知科学中的一个关键概念；然而，其神经基础仍然难以捉摸。我们采用了非侵入性脑电刺激和功能磁共振成像来解决这个问题。在这个过程中，参与者感知闪烁的红色和绿色视觉刺激，将它们辨别为不同的、不融合的颜色，或者是一种在头脑中产生的、融合的颜色（橙色）。经颅交流电刺激应用于内侧前额叶区域（默认模式网络的一个关键节点），抑制了与融合颜色感知相关的高级丘脑下核和中央执行网络的血液动力学激活。这意味着，较高阶的丘脑皮质和默认模式网络在人类对心理表象的有意识感知中是至关重要的。