Multiple Sclerosis Unit, Neurology Service, Hospital Universitario Virgen Macarena, Seville, Spain.
Multiple Sclerosis Unit, Neurology Service, Hospital Universitario Virgen Macarena, Seville, Spain.
Sleep Med. 2024 Jul;119:373-378. doi: 10.1016/j.sleep.2024.05.005. Epub 2024 May 8.
Multiple sclerosis (MS) causes sleep disturbances in up to 70 % of individuals. These problems are linked to fatigue, mood and cognitive performance, thereby affecting the quality of life in people with MS (PwMS). The frequent and debilitating side effects of sleep medications prompt the exploration of alternative therapies. Physical activity has shown benefits in improving sleep, reducing fatigue, and enhancing quality of life. Combined with a controlled exercise program tailored for PwMS, the study aims to analyze the impact of moderate physical exercise on sleep quality, cognitive function, quality of life, mood, and fatigue.
A single-center prospective cohort study was designed to assess the impact of a 12-week physical exercise program on patients with relapsing-remitting multiple sclerosis. Changes in sleep and activity parameters are evaluated using an actigraph and cognitive, quality of life, fatigue and mood changes are assessed through specific questionnaires before, during, and after the exercise program application.
23 patients completed the study (women = 84.6 %) Mean age was 37.2 years (SD 7.5). The mean EDSS score was 1.9, and 80.8 % were diagnosed within the last six years. Significant improvements were noted in sleep efficiency between baseline and final measurements (χ = 27.5; p.adj = 0.004), sleep latency (χ2 = 275; p.adj = 0.000), sleep duration (χ2 = 251; p.adj = 0.001) and in the number of awakenings (χ2 = 269.5; p.adj = 0.000), with a decreased in total time in bed from 8.5 h to 7.35 h post-intervention. Regarding activity variables, an increase in caloric expenditure and an increase in the time participants engaged in light activity were observed. We found significant improvements in fatigue, quality of life and mood. Concerning neuropsychological exploration results, improvements were observed in all studied parameters, with statistically significant improvement in Verbal SRT (χ2 = 43; p = 0.022).
Our study showed a positive impact of a 12-week physical exercise program on sleep performance, cognition and mood in PwMS. The observed improvements underscore the potential of tailored exercise interventions in promoting a more comprehensive and holistic care paradigm for PwMS.
多发性硬化症（MS）会导致多达 70%的个体出现睡眠障碍。这些问题与疲劳、情绪和认知表现有关，从而影响多发性硬化症患者（PwMS）的生活质量。由于睡眠药物的频繁和衰弱副作用，促使人们探索替代疗法。身体活动已显示出改善睡眠、减轻疲劳和提高生活质量的益处。结合为 PwMS 量身定制的受控运动计划，本研究旨在分析适度身体锻炼对睡眠质量、认知功能、生活质量、情绪和疲劳的影响。
设计了一项单中心前瞻性队列研究，以评估为期 12 周的身体锻炼计划对复发性缓解型多发性硬化症患者的影响。使用活动记录仪评估睡眠和活动参数的变化，通过特定问卷评估认知、生活质量、疲劳和情绪变化，在运动计划应用之前、期间和之后进行。
23 名患者完成了研究（女性=84.6%），平均年龄为 37.2 岁（标准差 7.5）。平均 EDSS 评分为 1.9，80.8%在过去六年内被诊断出。在睡眠效率（χ=27.5；p.adj=0.004）、睡眠潜伏期（χ2=275；p.adj=0.000）、睡眠持续时间（χ2=251；p.adj=0.001）和觉醒次数（χ2=269.5；p.adj=0.000）方面，从基线到最终测量均有显著改善，总卧床时间从干预后 8.5 小时减少到 7.35 小时。关于活动变量，观察到热量消耗增加和参与者从事轻度活动的时间增加。我们发现疲劳、生活质量和情绪有显著改善。关于神经心理学探索结果，所有研究参数均有改善，言语 SRT 有统计学显著改善（χ2=43；p=0.022）。
我们的研究表明，为期 12 周的身体锻炼计划对 PwMS 的睡眠表现、认知和情绪有积极影响。观察到的改善突出了量身定制的运动干预在促进更全面和整体的 PwMS 护理模式方面的潜力。
