Dermatology Department, University of California Davis Health, Sacramento, California, USA.
Dermatol Online J. 2024 Mar 15;30(1). doi: 10.5070/D330163286.
Tumor necrosis factor (TNF) inhibitors may paradoxically induce pustular eruptions, most of which are classified as pustular psoriasis. Amicrobial pustulosis of the folds (APF) is a much rarer entity that was recently recognized to occur in the setting of chronic anti-TNF therapy and inflammatory bowel disease, with 12 existing cases in the literature. Amicrobial pustulosis of the folds is a neutrophilic dermatosis characterized by aseptic pustules involving the major and minor skin folds, genital regions, and scalp. Herein, we report an additional case of paradoxical APF induced by chronic infliximab therapy in a patient with Crohn disease.
肿瘤坏死因子（TNF）抑制剂可能会产生矛盾性的脓疱发作，其中大多数被归类为脓疱性银屑病。皱褶部位非微生物性脓疱病（APF）是一种罕见的实体，最近被认为在慢性抗 TNF 治疗和炎症性肠病的背景下发生，文献中有 12 例现有病例。皱褶部位非微生物性脓疱病是一种中性粒细胞性皮肤病，其特征为无菌脓疱，累及主要和次要皮肤皱褶、生殖器区域和头皮。在此，我们报告了一例克罗恩病患者在接受慢性英夫利昔单抗治疗后发生的另外一例矛盾性 APF 病例。
