炎症性肠病对女性生殖生活的影响：一项基于问卷调查的研究。
Impact of inflammatory bowel disease on women's reproductive life: a questionnaire-based study.
作者信息
Zingone Fabiana, Borsato Alessandro, Maniero Daria, Della Loggia Francesco, Lorenzon Greta, Zanini Annalisa, Canova Cristina, Barberio Brigida, Savarino Edoardo Vincenzo
机构信息
Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Via Giustiniani 2, Padua 235128, Italy.
Gastroenterology Unit, Azienda Ospedale Università Padova, Padova, Italy.
出版信息
Therap Adv Gastroenterol. 2024 May 18;17:17562848241249440. doi: 10.1177/17562848241249440. eCollection 2024.
BACKGROUND
Inflammatory bowel diseases (IBDs) have a peak incidence between the second and fourth decades of life and can affect women's reproductive life.
OBJECTIVES
Our study aimed to assess the impact of IBD on the reproductive life of female patients with this condition.
DESIGN
Cross-sectional study.
METHODS
Women with IBD followed at our IBD Unit and a group of healthy controls were enrolled. Data on reproductive life were collected using a dedicated questionnaire.
RESULTS
The study included 457 women, of whom 228 had IBD, and 229 age-matched healthy controls. No differences were found in the use of contraceptives, infertility, and endometriosis. The risk of spontaneous and voluntary abortions was significantly higher in IBD patients than in healthy controls [odds ratio (OR) 2 and 3.62, respectively]. The risk of obstetrical complications in the IBD population was more than six times higher in patients who experienced disease reactivations during pregnancy than in those with persistent remission [OR 6.9, 95% confidence interval (CI) 1.51-31.28]. Finally, we found that the chances of breastfeeding were 66% lower in patients with IBD than in controls (OR 0.44, 95% CI 0.22-0.91).
CONCLUSION
Our study underlines the negative impact of IBD on women's reproductive life, supporting the need for proactive preconception counseling.
背景
炎症性肠病（IBD）在20至40岁之间发病率最高，且会影响女性的生殖生活。
目的
我们的研究旨在评估IBD对患有这种疾病的女性患者生殖生活的影响。
设计
横断面研究。
方法
纳入在我们的IBD科室就诊的IBD女性患者以及一组健康对照者。使用专门的问卷收集生殖生活数据。
结果
该研究纳入了457名女性，其中228名患有IBD，229名年龄匹配的健康对照者。在避孕药使用、不孕和子宫内膜异位方面未发现差异。IBD患者自然流产和人工流产的风险显著高于健康对照者[优势比（OR）分别为2和3.62]。IBD患者群体中，孕期疾病复发的患者发生产科并发症的风险比持续缓解的患者高出六倍多[OR 6.9，95%置信区间（CI）1.51 - 31.28]。最后，我们发现IBD患者进行母乳喂养的几率比对照者低66%（OR 0.44，95% CI 0.22 - 0.91）。
结论
我们的研究强调了IBD对女性生殖生活的负面影响，支持进行积极的孕前咨询的必要性。
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