Zhang Qiao, Xu Wengang, Liu Qiong, Xia Congjian, Shao Qi, Ma Lishuang, Wu Mingbo
College of New Energy, State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao, P. R. China.
Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology (China), Institute of Analysis, Guangdong Academy of Sciences (China National Analytical Center, Guangzhou), Guangzhou, P. R. China.
Nat Commun. 2024 May 22;15(1):4371. doi: 10.1038/s41467-024-48769-1.
A protocol for trans-hydroboration of indole derivatives using heterogeneous photocatalysis with NHC-borane has been developed, addressing a persistent challenge in organic synthesis. The protocol, leveraging high crystalline vacancy-engineered polymeric carbon nitride as a catalyst, enables diastereoselective synthesis, expanding substrate scope and complementing existing methods. The approach emphasizes eco-friendliness, cost-effectiveness, and scalability, making it suitable for industrial applications, particularly in renewable energy contexts. The catalyst's superior performance, attributed to its rich carbon-vacancies and well-ordered structure, surpasses more expensive homogeneous alternatives, enhancing viability for large-scale use. This innovation holds promise for synthesizing bioactive compounds and materials relevant to medicinal chemistry and beyond.
已经开发出一种使用NHC-硼烷进行多相光催化吲哚衍生物反式硼氢化反应的方案，解决了有机合成中一个长期存在的挑战。该方案利用高结晶度的空位工程化聚合氮化碳作为催化剂，能够实现非对映选择性合成，扩大了底物范围，并补充了现有方法。该方法强调生态友好、成本效益和可扩展性，使其适用于工业应用，特别是在可再生能源领域。该催化剂的优异性能归因于其丰富的碳空位和有序结构，优于更昂贵的均相替代品，提高了大规模使用的可行性。这一创新有望合成与药物化学及其他领域相关的生物活性化合物和材料。
