Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism, Karolinska Institutet, Solnavägen 9, Solna 171 65, Sweden.
Hum Mol Genet. 2024 May 22;33(R1):R42-R46. doi: 10.1093/hmg/ddae032.
Mitochondrial translation is a complex process responsible for the synthesis of essential proteins involved in oxidative phosphorylation, a fundamental pathway for cellular energy production. Central to this process is the termination phase, where dedicated factors play a pivotal role in ensuring accurate and timely protein production. This review provides a comprehensive overview of the current understanding of translation termination in human mitochondria, emphasizing structural features and molecular functions of two mitochondrial termination factors mtRF1 and mtRF1a.
线粒体翻译是一个复杂的过程，负责合成参与氧化磷酸化的必需蛋白质，氧化磷酸化是细胞能量产生的基本途径。这个过程的核心是终止阶段，专门的因子在确保蛋白质准确和及时的产生中起着关键作用。这篇综述提供了对人线粒体翻译终止的当前理解的全面概述，强调了两个线粒体终止因子 mtRF1 和 mtRF1a 的结构特征和分子功能。
