Suppr超能文献

精神分裂症患者在工作记忆任务中注意力轻度缺陷时的神经补偿现象。

The neural compensation phenomenon in schizophrenia with mild attention deficits during working memory task.

机构信息

Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.

Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.

出版信息

Asian J Psychiatr. 2024 Jul;97:104077. doi: 10.1016/j.ajp.2024.104077. Epub 2024 May 18.

Abstract

BACKGROUND

Working memory (WM) and attention are essential cognitive processes, and their interplay is critical for efficient information processing. Schizophrenia often exhibits deficits in both WM and attention, contributing to function impairments. This study aims to investigate the neural mechanisms underlying the relationship between WM impairments and attention deficits in schizophrenia.

METHODS

We assessed the functional-MRI scans of the 184 schizophrenias with different attention deficits (mild=133; severe=51) and 146 controls during an N-back WM task. We explored their whole-brain functional connectome profile by adopting the voxel-wise degree centrality (DC). Linear analysis was conducted to explore the associations among attention deficit severity, altered DC, and WM performance in patients.

RESULTS

We observed that all patients showed decreased DC in the pre-supplementary area (pre-SMA), and posterior cerebellum compared to the controls, and schizophrenia patients with mild attention deficits showed decreased DC in the supramarginal gyrus, insula, and precuneus compared with the other 2 groups. DC values of the detected brain regions displayed U-shaped or inverted U-shaped curves, rather than a linear pattern, in response to increasing attention deficits. The linear analysis indicated that altered DC of the pre-SMA can modulate the relationship between attention deficits and WM performance.

CONCLUSION

The U-shaped or inverted U-shaped pattern in response to increasing attention deficits may reflect a compensation mechanism in schizophrenia with mild attention deficits. This notion is also supported by the linear analysis that schizophrenia patients with mild attention deficits can improve their WM performance by increasing the DC value of the pre-SMA.

摘要

背景

工作记忆 (WM) 和注意力是至关重要的认知过程,它们的相互作用对于有效的信息处理至关重要。精神分裂症患者通常在 WM 和注意力方面都存在缺陷,这导致了他们的功能障碍。本研究旨在探讨精神分裂症患者 WM 损伤与注意力缺陷之间关系的神经机制。

方法

我们评估了 184 名注意力缺陷不同的精神分裂症患者(轻度=133;重度=51)和 146 名对照者在进行 N-back WM 任务时的功能磁共振成像扫描。我们通过采用体素水平的度中心度 (DC) 来探索他们的全脑功能连接组谱。线性分析用于探讨患者注意力缺陷严重程度、改变的 DC 与 WM 表现之间的关联。

结果

我们观察到所有患者与对照组相比,在前补充运动区 (pre-SMA) 和后小脑的 DC 降低,而注意力缺陷轻度的精神分裂症患者与其他 2 组相比,在缘上回、岛叶和楔前叶的 DC 降低。检测到的大脑区域的 DC 值呈现出 U 形或倒 U 形曲线,而不是线性模式,以响应注意力缺陷的增加。线性分析表明,pre-SMA 的改变 DC 可以调节注意力缺陷与 WM 表现之间的关系。

结论

对注意力缺陷的增加呈 U 形或倒 U 形模式可能反映了轻度注意力缺陷的精神分裂症的补偿机制。这种观点也得到了线性分析的支持,即轻度注意力缺陷的精神分裂症患者可以通过增加 pre-SMA 的 DC 值来提高他们的 WM 表现。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验