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在印度德里东部的一家三级护理医院中，通过含多黏菌素 B 药敏纸片洗脱法（colistin broth disk elution MIC method）对耐碳青霉烯类革兰氏阴性菌血培养临床分离株进行多黏菌素药敏试验。

Colistin Susceptibility Testing by Colistin Broth Disk Elution MIC Method among Carbapenem-resistant Gram-negative Blood Culture Clinical Isolates in a Tertiary Care Setting, East Delhi, India.

机构信息

Department of Microbiology University College of Medical Sciences and Guru Tag Bahadur Hospital Delhi 110095.

出版信息

Ethiop J Health Sci. 2023 Sep;33(5):743-750. doi: 10.4314/ejhs.v33i5.4.

DOI:10.4314/ejhs.v33i5.4
PMID:38784504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11111212/
Abstract

BACKGROUND: Antibiotic resistance is a growing concern for bloodstream infections (BSIs), especially with the emergence of multidrug-resistant (MDR) gram-negative bacteria. In this study, we aimed to assess the pattern of colistin susceptibility using the colistin broth disc elution (CBDE) method among carbapenem-resistant gram-negative clinical isolates from blood cultures in a high burden tertiary healthcare setting in East Delhi. METHODS: A total of 106 carbapenem-resistant gram-negative clinical isolates were tested. The most common isolates were Klebsiella pneumoniae, Escherichia coli, Enterobacter species, and Klebsiella oxytoca by CBDE method. RESULT: All the carbapenem resistant gram-negative bacterial blood culture isolates showed intermediate colistin susceptibility. This was statistically significant by chi-square test (p<0.5). CONCLUSION: This study highlights the need to monitor colistin resistance trends in the face of increasing antimicrobial resistance. Accurate surveillance of emerging colistin resistance is crucial for effective management of BSIs caused by carbapenem-resistant gram-negative bacteria.

摘要

背景：抗生素耐药性是血流感染（BSI）日益关注的问题，尤其是出现多药耐药（MDR）革兰氏阴性菌时。在这项研究中，我们旨在评估高负担三级保健环境中来自血培养的碳青霉烯类耐药革兰氏阴性临床分离株中使用多粘菌素肉汤稀释洗脱（CBDE）方法的多粘菌素敏感性模式。

方法：共检测了 106 株碳青霉烯类耐药革兰氏阴性临床分离株。通过 CBDE 方法，最常见的分离株为肺炎克雷伯菌、大肠杆菌、肠杆菌属和产酸克雷伯菌。

结果：所有碳青霉烯类耐药革兰氏阴性菌血培养分离株均表现出中介度多粘菌素敏感性。卡方检验（p<0.5）表明这具有统计学意义。

结论：本研究强调了在面临日益增加的抗菌药物耐药性时需要监测多粘菌素耐药趋势。准确监测新出现的多粘菌素耐药性对于有效管理由碳青霉烯类耐药革兰氏阴性菌引起的 BSI 至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ea/11111212/66d79cf6a6a0/EJHS3305-0743Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ea/11111212/900f8cff9fd1/EJHS3305-0743Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ea/11111212/8448af0892d7/EJHS3305-0743Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ea/11111212/66d79cf6a6a0/EJHS3305-0743Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ea/11111212/900f8cff9fd1/EJHS3305-0743Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ea/11111212/8448af0892d7/EJHS3305-0743Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02ea/11111212/66d79cf6a6a0/EJHS3305-0743Fig3.jpg

相似文献

[1]
Colistin Susceptibility Testing by Colistin Broth Disk Elution MIC Method among Carbapenem-resistant Gram-negative Blood Culture Clinical Isolates in a Tertiary Care Setting, East Delhi, India.

Ethiop J Health Sci. 2023-9

[2]
Comparative evaluation of microscan walkaway 96 plus ID/AST system and mikrolatest broth microdilution kit in assessing colistin susceptibility of carbapenem-resistant clinical gram-negative bacterial isolates: Experience from a tertiary care teaching hospital in Rishikesh, Uttarakhand.

Indian J Med Microbiol. 2019

[3]
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[4]
Analysis of mcr family of colistin resistance genes in Gram-negative isolates from a tertiary care hospital in India.

J Appl Microbiol. 2024-7-2

[5]
Nationwide surveillance of antimicrobial resistance among clinically important Gram-negative bacteria, with an emphasis on carbapenems and colistin: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART) in 2018.

Int J Antimicrob Agents. 2019-6-14

[6]
The distribution of carbapenem- and colistin-resistance in Gram-negative bacteria from the Tamil Nadu region in India.

J Med Microbiol. 2017-7

[7]
Treatment and Outcome of Carbapenem-Resistant Gram-Negative Bacilli Blood-Stream Infections in a Tertiary Care Hospital.

J Assoc Physicians India. 2015-7

[8]
Two-Site Evaluation of the Colistin Broth Disk Elution Test To Determine Colistin Activity against Gram-Negative Bacilli.

J Clin Microbiol. 2019-1-30

[9]
Antimicrobial susceptibility profiles of gram-negative bacteria causing infections collected across India during 2014-2016: Study for monitoring antimicrobial resistance trend report.

Indian J Med Microbiol. 2018

[10]
In vitro assessment of newer colistin-sparing antimicrobial agents for clinical isolates of carbapenem-resistant organisms.

J Infect Chemother. 2024-12

本文引用的文献

[1]
Global Prevalence of Colistin Resistance in from Bloodstream Infection: A Systematic Review and Meta-Analysis.

Pathogens. 2022-9-24

[2]
Colistin Resistance Among Multi-Drug Resistant Gram-Negative Bacterial Isolates From Different Clinical Samples of ICU Patients: Prevalence and Clinical Outcomes.

Cureus. 2022-8-23

[3]
A Bibliometric Meta-Analysis of Colistin Resistance in .

Diseases. 2021-6-20

[4]
Mutations in two component system (PhoPQ and PmrAB) in colistin resistant Klebsiella pneumoniae from North Indian tertiary care hospital.

J Antibiot (Tokyo). 2021-7

[5]
Early prediction of blood stream infection in a prospectively collected cohort.

BMC Infect Dis. 2021-4-2

[6]
Bloodstream infections in critically ill patients: an expert statement.

Intensive Care Med. 2020-2-11

[7]
Emergence of colistin resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coli strains isolated from cancer patients.

Ann Clin Microbiol Antimicrob. 2019-12-12

[8]
Two-Site Evaluation of the Colistin Broth Disk Elution Test To Determine Colistin Activity against Gram-Negative Bacilli.

J Clin Microbiol. 2019-1-30

[9]
Evaluating the Trends of Bloodstream Infections among Pediatric and Adult Patients at a Teaching Hospital of Kathmandu, Nepal: Role of Drug Resistant Pathogens.

Can J Infect Dis Med Microbiol. 2017

[10]
Phenotypic Detection of Extended Spectrum Beta lactamase and Carbapenemase Co-producing Clinical Isolates from Two Tertiary Hospitals in Kano, North West Nigeria.

Ethiop J Health Sci. 2017-1

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