Pasten González Albert, Salvador Alarcón Cristina, Mora Jaume, Martín Gimenez Marta P, Carrasco Torrents Rosalia, Krauel Lucas
Pediatric Surgical Oncology Unit, Department of Pediatric Surgery, SJD Barcelona Children's Hospital, Universitat de Barcelona, 08950 Barcelona, Spain.
Pediatric Cancer Center Barcelona, SJD Barcelona Children's Hospital, Universitat de Barcelona, 08950 Barcelona, Spain.
Children (Basel). 2024 Apr 30;11(5):537. doi: 10.3390/children11050537.
Cancer poses significant emotional challenges for children and adolescents, despite improvements in survival rates due to new therapies. However, there is growing concern about the long-term effects, including fertility issues. This review examines recent advancements and future directions in fertility preservation within a pediatric population subjected to oncological therapies. Worldwide, there is variability in the availability of fertility preservation methods, influenced by factors like development status and governmental support. The decision to pursue preservation depends on the risk of gonadotoxicity, alongside factors such as diagnosis, treatment, clinical status, and prognosis. Currently, options for preserving fertility in prepubertal boys are limited compared to girls, who increasingly have access to ovarian tissue preservation. Adolescents and adults have more options available, but ethical considerations remain complex and diverse.
尽管新疗法提高了生存率,但癌症给儿童和青少年带来了重大的情感挑战。然而,人们越来越关注其长期影响,包括生育问题。本综述探讨了接受肿瘤治疗的儿科人群中生育力保存的最新进展和未来方向。在全球范围内,生育力保存方法的可及性存在差异,这受到发展状况和政府支持等因素的影响。是否进行生育力保存的决定取决于性腺毒性风险,以及诊断、治疗、临床状况和预后等因素。目前,与女孩相比,青春期前男孩的生育力保存选择有限,而女孩越来越有机会进行卵巢组织保存。青少年和成年人有更多的选择,但伦理考量仍然复杂多样。