Zhuang Zhen, Zhuo Jianfen, Yuan Yaochang, Chen Zhao, Zhang Shengnan, Zhu Airu, Zhao Jingxian, Zhao Jincun
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, China.
Guangzhou National Laboratory, Guangzhou 510005, China.
Vaccines (Basel). 2024 Apr 29;12(5):478. doi: 10.3390/vaccines12050478.
Despite significant strides in vaccine research and the availability of vaccines for many infectious diseases, the threat posed by both known and emerging infectious diseases persists. Moreover, breakthrough infections following vaccination remain a concern. Therefore, the development of novel vaccines is imperative. These vaccines must exhibit robust protective efficacy, broad-spectrum coverage, and long-lasting immunity. One promising avenue in vaccine development lies in leveraging T-cells, which play a crucial role in adaptive immunity and regulate immune responses during viral infections. T-cell recognition can target highly variable or conserved viral proteins, and memory T-cells offer the potential for durable immunity. Consequently, T-cell-based vaccines hold promise for advancing vaccine development efforts. This review delves into the latest research advancements in T-cell-based vaccines across various platforms and discusses the associated challenges.
尽管疫苗研究取得了重大进展，并且有多种传染病疫苗可供使用，但已知和新出现的传染病所构成的威胁依然存在。此外，接种疫苗后的突破性感染仍是一个令人担忧的问题。因此，开发新型疫苗势在必行。这些疫苗必须具备强大的保护效力、广谱覆盖范围和持久的免疫力。疫苗开发的一个有前景的途径在于利用T细胞，T细胞在适应性免疫中起关键作用，并在病毒感染期间调节免疫反应。T细胞识别可以针对高度可变或保守的病毒蛋白，记忆T细胞具有产生持久免疫力的潜力。因此，基于T细胞的疫苗有望推动疫苗开发工作。本综述深入探讨了基于T细胞的疫苗在各种平台上的最新研究进展，并讨论了相关挑战。
