Harnett Anne, Byrne Stephen, O'Connor Jennifer, Burke Eimear, South Laura, Lyons Declan, Sahm Laura J
University Hospital Limerick, Dooradoyle, V94 F858 Limerick, Ireland.
Pharmaceutical Care Research Group, School of Pharmacy, University College Cork, T12 YN60 Cork, Ireland.
Pharmaceutics. 2024 Apr 25;16(5):584. doi: 10.3390/pharmaceutics16050584.
The safe administration of solid oral dose forms in hospital inpatients with swallowing difficulties is challenging. The aim of this study was to establish the prevalence of difficulties in swallowing solid oral dose forms in acute hospital inpatients. A point prevalence study was completed at three time points. The following data were collected: the prevalence of swallowing difficulties, methods used to modify solid oral dose forms to facilitate administration, the appropriateness of the modification, and patient co-morbidities. The prevalence of acute hospital inpatients with swallowing difficulties was an average of 15.4% with a 95% CI [13.4, 17.6] across the three studies. On average, 9.6% of patients with swallowing difficulties had no enteral feeding tube in situ, with 6.0% of these patients receiving at least one modified medicine. The most common method of solid oral dose form modification was crushing, with an administration error rate of approximately 14.4%. The most common co-morbid condition in these patients was hypertension, with dysphagia appearing on the problem list of two (5.5%) acute hospital inpatients with swallowing difficulties. Inappropriate modifications to solid oral dose forms to facilitate administration can result in patient harm. A proactive approach, such as the use of a screening tool to identify acute hospital inpatients with swallowing difficulties, is required, to mitigate the risk of inappropriate modifications to medicines to overcome swallowing difficulties.
在吞咽困难的住院患者中安全服用固体口服剂型具有挑战性。本研究的目的是确定急性住院患者中吞咽固体口服剂型困难的发生率。在三个时间点完成了一项现况研究。收集了以下数据:吞咽困难的发生率、为便于给药而对固体口服剂型进行调整的方法、调整的适当性以及患者的合并症。在三项研究中,急性住院患者吞咽困难的平均发生率为15.4%,95%置信区间为[13.4, 17.6]。平均而言,9.6%吞咽困难的患者没有留置肠内喂养管,其中6.0%的患者接受了至少一种调整后的药物。固体口服剂型调整最常用的方法是碾碎,给药错误率约为14.4%。这些患者最常见的合并症是高血压,在两名(5.5%)急性住院吞咽困难患者的问题清单上出现了吞咽困难。为便于给药而对固体口服剂型进行不适当的调整可能会对患者造成伤害。需要采取积极主动的方法,例如使用筛查工具来识别急性住院吞咽困难患者,以降低为克服吞咽困难而对药物进行不适当调整的风险。