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眼动追踪证据表明，治疗抵抗性抑郁症患者对情绪面孔的注意力偏向与抑郁严重程度之间存在关系。

Eye-tracking evidence of a relationship between attentional bias for emotional faces and depression severity in patients with treatment-resistant depression.

机构信息

Université Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, PSYR2, 69500, Bron, France.

Centre Hospitalier Le Vinatier, Bat 416 1st floor, 95 boulevard Pinel, 696500, Bron, France.

出版信息

Sci Rep. 2024 May 25;14(1):12000. doi: 10.1038/s41598-024-62251-4.

DOI:10.1038/s41598-024-62251-4
PMID:38796509
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11127986/
Abstract

In a retrospective study, 54 patients with treatment-resistant major depressive disorder (TRD) completed a free-viewing task in which they had to freely explore pairs of faces (an emotional face (happy or sad) opposite to a neutral face). Attentional bias to emotional faces was calculated for early and sustained attention. We observed a significant negative correlation between depression severity as measured by the 10-item Montgomery-Åsberg Depression Rating Scale (MADRS) and sustained attention to happy faces. In addition, we observed a positive correlation between depression severity and sustained attention to sad faces. No significant correlation between depression severity and early attention was found for either happy or sad faces. Although conclusions from the current study are limited by the lack of comparison with a control group, the eye-tracking free-viewing task appears to be a relevant, accessible and easy-to-use tool for measuring depression severity through emotional attentional biases in TRD.

摘要

在一项回顾性研究中，54 名治疗抵抗性重度抑郁症（TRD）患者完成了一项自由观看任务，他们必须自由地查看一对面孔（一张快乐或悲伤的情绪面孔与一张中性面孔相对）。对面孔的注意力偏向被计算为早期注意力和持续注意力。我们观察到，10 项蒙哥马利-Åsberg 抑郁评定量表（MADRS）测量的抑郁严重程度与对快乐的面孔的持续注意力呈显著负相关。此外，我们还观察到抑郁严重程度与对悲伤面孔的持续注意力呈正相关。无论是快乐面孔还是悲伤面孔，抑郁严重程度与早期注意力之间均无显著相关性。尽管由于缺乏与对照组的比较，当前研究的结论受到限制，但眼动追踪自由观看任务似乎是一种相关、可及且易于使用的工具，可通过 TRD 中情绪注意力偏向来衡量抑郁严重程度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da86/11127986/ee52ae5df19d/41598_2024_62251_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da86/11127986/ee52ae5df19d/41598_2024_62251_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da86/11127986/ee52ae5df19d/41598_2024_62251_Fig1_HTML.jpg

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World Psychiatry. 2023 Oct;22(3):394-412. doi: 10.1002/wps.21120.
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Reliability of attention bias and attention bias variability to climate change images in the dot-probe task.点探测任务中对气候变化图像的注意偏向和注意偏向变异性的可靠性
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The neurobiology of treatment-resistant depression: A systematic review of neuroimaging studies.
将愉悦嗅觉与脑刺激相结合治疗难治性抑郁症（COBRA）：一项随机对照试验的研究方案
Front Psychol. 2024 Dec 17;15:1451096. doi: 10.3389/fpsyg.2024.1451096. eCollection 2024.
治疗抵抗性抑郁症的神经生物学：神经影像学研究的系统综述。
Neurosci Biobehav Rev. 2022 Jan;132:433-448. doi: 10.1016/j.neubiorev.2021.12.008. Epub 2021 Dec 7.
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Attention bias modification in depression: A randomized trial using a novel, reward-based, eye-tracking approach.抑郁的注意偏向修正：一项采用新型基于奖励的眼动追踪方法的随机试验。
J Behav Ther Exp Psychiatry. 2021 Jun;71:101621. doi: 10.1016/j.jbtep.2020.101621. Epub 2020 Oct 24.
5
Aberrant attentional bias to sad faces in depression and the role of stressful life events: Evidence from an eye-tracking paradigm.抑郁症患者对悲伤面孔的异常注意偏向及应激性生活事件的作用：来自眼动追踪范式的证据。
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