尼日利亚五岁以下儿童的疟疾寄生虫血症及严重健康并发症:一项利用2021年人口与健康调查(DHS)疟疾指标调查(MIS)开展的研究

Malaria Parasitemia and Severe Health Complications in Children Under Five Years of Age in Nigeria: A Study Using the Demographic and Health Survey (DHS) Malaria Indicator Survey (MIS) 2021.

作者信息

Olagunju Olajide J, Ekwebene Onyeka C, Olagunju Olayinka E, Osanyinlusi Olagoke, Oyebanji Oladayo A, Egbo Ben

机构信息

Infectious Disease, Case Western Reserve University School of Medicine, Cleveland, USA.

Biostatistics and Epidemiology, East Tennessee State University, Johnson City, USA.

出版信息

Cureus. 2024 Apr 24;16(4):e58907. doi: 10.7759/cureus.58907. eCollection 2024 Apr.

Abstract

BACKGROUND

In Nigeria, 97% of the population is at risk of contracting malaria. It is transmitted by female mosquitoes carrying the parasite and can be lethal. An estimated 55 million illnesses and 80,000 deaths per year result from it. Children under five are more likely to contract malaria. Efforts to control malaria in Nigeria include indoor residual spraying, insecticide-treated bed nets, and quick detection and treatment of confirmed cases with effective antimalarial medications. These attempts have been impeded by limited healthcare access, poor financing, and drug-resistant parasites. Thus, the study of the relationship between malaria complications and housing for children under five is essential.

METHODS

The Demographic and Health Survey (DHS) Malaria Indicator Survey (MIS) 2021, a nationally representative data set from developing countries on population and health, was used for this study. A sample size of 13,727 was employed (n=13,727). Logistic regression analyses were conducted to test the association between the type of place of residence and malaria complications (outcome).

RESULTS

Overall, 4.2% (n=570, weight HV005) of participants in the sample reported malaria complications. The results of the logistic regression revealed that children residing in urban settlements (aOR 0.37, 95% CI 0.37-0.37, p-value <0.001), children from the poorest class families (aOR 11.63, 95% CI 1.62-1.63, p-value 0.004), children from poorer class families (aOR 7.56, 95% CI 7.55-7.57, p-value <0.001), children from middle-class families (aOR 4.05, 95% CI 4.03-9.06, p-value <0.001), children from richer class families (aOR 1.22, 95% CI 2.21-2.23, p-value <0.001), children of mothers with primary education (aOR 0.42, 95% CI 2.32-4.112, p-value 0.001), children of mothers with secondary education (aOR 0.24, 95% CI 3.21-3.22, p-value <0.001), children of mothers with higher education (aOR 0.08, 95% CI 0.72-0.80, p-value <0.001), and children of the female gender (aOR 0.65, 95% CI 0.65-0.66, p-value <0.001) are all associated with severe malaria complications.

CONCLUSIONS

In conclusion, the study examined malaria complications in Nigerian children under five by residency. The findings imply that rural children are more likely to have serious malaria complications than urban children. This emphasizes the necessity for targeted malaria therapies in rural areas with limited healthcare access.

摘要

背景

在尼日利亚,97%的人口有感染疟疾的风险。疟疾由携带疟原虫的雌性蚊子传播,可能致命。据估计,每年因疟疾导致5500万例疾病和8万例死亡。五岁以下儿童更易感染疟疾。尼日利亚控制疟疾的努力包括室内滞留喷洒、经杀虫剂处理的蚊帐,以及用有效的抗疟药物对确诊病例进行快速检测和治疗。但这些努力受到医疗服务可及性有限、资金不足和疟原虫耐药性的阻碍。因此,研究五岁以下儿童疟疾并发症与住房之间的关系至关重要。

方法

本研究使用了《人口与健康调查》(DHS)2021年疟疾指标调查(MIS),这是一个来自发展中国家的关于人口与健康的具有全国代表性的数据集。样本量为13727(n = 13727)。进行逻辑回归分析以检验居住地点类型与疟疾并发症(结果)之间的关联。

结果

总体而言,样本中的4.2%(n = 570,权重HV005)参与者报告有疟疾并发症。逻辑回归结果显示,居住在城市地区的儿童(调整后比值比[aOR]为0.37,95%置信区间[CI]为0.37 - 0.37,p值<0.001)、来自最贫困家庭的儿童(aOR为11.63,95% CI为1.62 - 1.63,p值0.004)、来自较贫困家庭的儿童(aOR为7.56,95% CI为7.55 - 7.57,p值<0.001)、来自中等收入家庭的儿童(aOR为4.05,95% CI为4.03 - 9.06,p值<0.001)、来自较富裕家庭的儿童(aOR为1.22,95% CI为2.21 - 2.23,p值<0.001)、母亲为小学学历的儿童(aOR为0.42,95% CI为2.32 - 4.112,p值0.001)、母亲为初中学历的儿童(aOR为0.24,95% CI为3.21 - 3.22,p值<0.001)、母亲为高中学历的儿童(aOR为0.08,95% CI为0.72 - 0.80,p值<0.001)以及女童(aOR为0.65,95% CI为0.65 - 0.66,p值<0.001)均与严重疟疾并发症相关。

结论

总之,该研究按居住地调查了尼日利亚五岁以下儿童的疟疾并发症。研究结果表明,农村儿童比城市儿童更易出现严重疟疾并发症。这凸显了在医疗服务可及性有限的农村地区进行针对性疟疾治疗的必要性。

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