S Yogesh, S Venkatesan, A T Jayaraj, T S Karthigeyan, S Siva Prasath, S Suriya Prakash, R Selva Krishna, N Sandhiya, S Navvin, Prasad Roshan
Internal Medicine, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, IND.
Internal medicine, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, IND.
Cureus. 2024 Apr 24;16(4):e58916. doi: 10.7759/cureus.58916. eCollection 2024 Apr.
Background Diabetes mellitus remains a pressing global health issue, characterized by chronic metabolic dysfunction and the potential for life-threatening acute hyperglycemic emergencies. These emergencies, known as diabetic ketoacidosis and hyperosmolar hyperglycemic states, trigger a series of physiological disruptions. This article delves deeply into how the type and duration of diabetes mellitus affect the occurrence of hyperglycemic emergencies and mortality rates. Methods The study was conducted at the Institute of Internal Medicine, Rajiv Gandhi General Hospital, affiliated with Madras Medical College, spanning from July 2021 to December 2021. It encompassed both individuals newly diagnosed with diabetic ketoacidosis and patients already undergoing diabetic treatment who developed diabetic ketoacidosis and hyperosmolar hyperglycemic states. Results Within the study cohort of 110 patients, 37.27% were diagnosed with Type 1 diabetes mellitus, while 62.73% were classified as Type 2 diabetes mellitus patients. Among these individuals, 23.60% were newly diagnosed with diabetes, 22.70% had been diabetic for less than one year, 47.30% had a diabetic history of two to five years, and 6.40% had been diabetic for over six years. However, upon investigating the relationship between diabetes duration and mortality rate, no statistically significant findings were observed. Conclusion Hyperglycemic emergencies represent multifaceted clinical challenges influenced by the interplay of various factors, including the type and duration of the disease. By maintaining effective management of hyperglycemia from the outset and sustaining it throughout their lives, people with diabetes can improve their physical and mental health and reduce the likelihood of developing long-term complications that may negatively impact their overall well-being.
背景 糖尿病仍然是一个紧迫的全球健康问题,其特征为慢性代谢功能障碍以及可能引发危及生命的急性高血糖急症。这些急症,即糖尿病酮症酸中毒和高渗高血糖状态,会引发一系列生理紊乱。本文深入探讨糖尿病的类型和病程如何影响高血糖急症的发生及死亡率。
方法 该研究在隶属于马德拉斯医学院的拉吉夫·甘地综合医院内科进行,时间跨度为2021年7月至2021年12月。研究对象包括新诊断为糖尿病酮症酸中毒的个体以及已接受糖尿病治疗但后来发生糖尿病酮症酸中毒和高渗高血糖状态的患者。
结果 在110名患者的研究队列中,37.27%被诊断为1型糖尿病,而62.73%被归类为2型糖尿病患者。在这些个体中,23.60%为新诊断出的糖尿病患者,22.70%的糖尿病病程不到一年,47.30%的糖尿病病史为两到五年,6.40%的糖尿病病程超过六年。然而,在调查糖尿病病程与死亡率之间的关系时,未观察到具有统计学意义的结果。
结论 高血糖急症是受多种因素相互作用影响的多方面临床挑战,这些因素包括疾病的类型和病程。糖尿病患者从一开始就维持有效的血糖管理并终生坚持,可改善身心健康,并降低发生可能对其整体健康产生负面影响的长期并发症的可能性。