College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
Department of Basic Sciences, College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
Clin Interv Aging. 2024 May 23;19:923-938. doi: 10.2147/CIA.S460475. eCollection 2024.
Multiple sclerosis (MS) is a chronic inflammatory condition that causes demyelination of the central nervous system accompanied by a wide range of symptoms. The high prevalence of falls among patients diagnosed with MS within the initial six months highlights the importance of this issue. The objective of this study is to identify factors associated with falls in MS patients in order to increase awareness and reduce the risk of falls. This scoping review used specific Mesh terms to formulate the literature search around falls and MS using Medline, Google Scholar, Scopus, and Embase search engines. English papers published between 2012 and 2022, studies with a clear definition of falls, McDonald's diagnostic criteria for MS, and those with Expanded Disability Status Scale (EDSS) or Patient Determined Disease Steps (PDDS) scores were included. Critical data from the selected articles were extracted and classified according to the different factors associated with falls in MS patients. Eighteen articles were included in this review. The most important factors associated with falls in MS patients identified were the severity and progression of the disease, mobility and balance problems, bladder dysfunction, fear of falling, fatigue, and cognitive dysfunction. In conclusion, this scoping review yielded the most common factors associated with falls in patients with MS. Study findings can be used to develop future interventions focusing on improving mobility, proprioception, and balance to decrease fall risk and injury amongst MS patients.
多发性硬化症（MS）是一种慢性炎症性疾病，会导致中枢神经系统脱髓鞘，并伴有多种症状。在确诊后的最初六个月内，多发性硬化症患者的跌倒发生率很高，这凸显了这个问题的重要性。本研究旨在确定与多发性硬化症患者跌倒相关的因素，以提高认识并降低跌倒风险。本范围界定综述使用特定的 Mesh 术语，通过 Medline、Google Scholar、Scopus 和 Embase 搜索引擎围绕跌倒和多发性硬化症进行文献检索。纳入的英文文献发表于 2012 年至 2022 年之间，研究对跌倒有明确的定义、采用了麦克唐纳多发性硬化症诊断标准，以及使用扩展残疾状况量表（EDSS）或患者确定疾病步骤（PDDS）评分的研究。从选定的文章中提取关键数据，并根据与多发性硬化症患者跌倒相关的不同因素进行分类。本综述纳入了 18 篇文章。与多发性硬化症患者跌倒相关的最重要因素包括疾病的严重程度和进展、移动和平衡问题、膀胱功能障碍、跌倒恐惧、疲劳和认知功能障碍。总之，本范围界定综述得出了与多发性硬化症患者跌倒最相关的常见因素。研究结果可用于制定未来的干预措施，重点改善移动性、本体感觉和平衡，以降低多发性硬化症患者的跌倒风险和受伤风险。
