Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Biotechnol Appl Biochem. 2024 Oct;71(5):1164-1169. doi: 10.1002/bab.2618. Epub 2024 May 28.
Venous malformations are the most common congenital vascular malformations, and the incidence rate is high. Previous studies have confirmed that a variety of polymorphisms within the miRNA functional region are associated with tumor susceptibility. We examined the correlation between miR-618 rs2682818 C>A and risk of developing venous malformation in a southern Chinese population (1113 patients and 1158 controls). TaqMan genotyping of miR-618 rs2682818 C>A was conducted utilizing real-time fluorescent quantitative PCR. The miR-618 rs2682818 polymorphism was not correlated with susceptibility to venous malformation (CA/AA vs. CC: adjusted odds ratio [AOR] = 1.00, 95% confidence interval [CI] = 0.81-1.25, p = 0.994; AA vs. CC/CA: AOR = 1.10, 95% CI = 0.73-1.65, p = 0.646). Stratified analysis of different subtypes of venous malformation revealed that there was no significant difference in the rs2682818 C>A polymorphism genotypes across these subtypes. Our results indicate that miR-618 rs2682818 C>A polymorphism is not correlated with the susceptibility to venous malformation.
静脉畸形是最常见的先天性血管畸形，发病率较高。既往研究已证实 miRNA 功能区域的多种多态性与肿瘤易感性相关。我们在一个中国南方人群中（1113 例患者和 1158 例对照），研究了 miR-618 rs2682818 C>A 与静脉畸形发病风险之间的相关性。采用实时荧光定量 PCR 法对 miR-618 rs2682818 C>A 进行 TaqMan 基因分型。miR-618 rs2682818 多态性与静脉畸形易感性无关（CA/AA 与 CC：校正比值比[AOR]=1.00，95%置信区间[CI]为 0.81-1.25，p=0.994；AA 与 CC/CA：AOR=1.10，95%CI 为 0.73-1.65，p=0.646）。静脉畸形不同亚型的分层分析显示，这些亚型之间 rs2682818 C>A 多态性基因型无显著差异。我们的结果表明，miR-618 rs2682818 C>A 多态性与静脉畸形易感性无关。
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