Kardan Romina, Hemmati Jaber, Nazari Mohsen, Ahmadi Amjad, Asghari Babak, Azizi Mehdi, Khaledi Mansoor, Arabestani Mohammad Reza
Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
These authors contributed equally in this article.
Caspian J Intern Med. 2024 Spring;15(2):215-227. doi: 10.22088/cjim.15.2.215.
The interaction between commensal bacteria and the host is essential for health and the gut microbiota-brain axis plays a vital role in this regard. Obesity as a medical problem not only affect the health of the individuals, but also the economic and social aspects of communities. The presence of any dysbiosis in the composition of the gut microbiota disrupts in the gut microbiota-brain axis, which in turn leads to an increase in appetite and then obesity. Because common treatments for obesity have several drawbacks, the use of microbiota-based therapy in addition to treatment and prevention of obesity can have other numerous benefits for the individual. In this review, we intend to investigate the relationship between obesity and the gut microbiota-brain axis as well as novel treatment strategies based on this axis with an emphasis on gut microbiota.
共生细菌与宿主之间的相互作用对健康至关重要，而肠道微生物群-脑轴在这方面发挥着至关重要的作用。肥胖作为一个医学问题，不仅影响个体健康，还影响社区的经济和社会层面。肠道微生物群组成中的任何失调都会破坏肠道微生物群-脑轴，进而导致食欲增加，继而引发肥胖。由于肥胖的常规治疗存在若干弊端，除了治疗和预防肥胖外，使用基于微生物群的疗法对个体还可能有许多其他益处。在本综述中，我们打算研究肥胖与肠道微生物群-脑轴之间的关系，以及基于该轴的新型治疗策略，重点关注肠道微生物群。
