Glaser J B, Morton-Kute L, Berger S R, Weber J, Siegal F P, Lopez C, Robbins W, Landesman S H
Ann Intern Med. 1985 Feb;102(2):189-93. doi: 10.7326/0003-4819-102-2-189.
Seven Haitian and one white patient with the acquired immunodeficiency syndrome and Salmonella typhimurium bacteremia were identified over a 28-month period. In three patients bacteremia developed concurrently with an opportunistic infection associated with the acquired immunodeficiency syndrome. The remaining five patients had their initial episodes of bacteremia 3 to 11 months before the diagnosis of the acquired immunodeficiency syndrome. These five patients had signs suggestive of the syndrome, plus evidence of disordered cellular immune function (lymphopenia, anergy, decreased T-helper cells, decreased proliferative responses, and a deficiency in mononuclear-cell alpha interferon production). Salmonella typhimurium bacteremia in the appropriate clinical setting may be an opportunistic pathogen associated with the acquired immunodeficiency syndrome.
在28个月的时间里，共发现7名海地裔和1名白人患者患有获得性免疫缺陷综合征并伴有鼠伤寒沙门菌菌血症。3名患者的菌血症与获得性免疫缺陷综合征相关的机会性感染同时发生。其余5名患者在获得性免疫缺陷综合征诊断前3至11个月首次发生菌血症。这5名患者有该综合征的提示性体征，以及细胞免疫功能紊乱的证据（淋巴细胞减少、无反应性、辅助性T细胞减少、增殖反应降低和单核细胞α干扰素产生不足）。在适当的临床环境中，鼠伤寒沙门菌菌血症可能是一种与获得性免疫缺陷综合征相关的机会性病原体。
