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在胰高血糖素样肽 1 受体激动剂时代治疗肥胖和生育问题。

Treating obesity and fertility in the era of glucagon-like peptide 1 receptor agonists.

机构信息

Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

Center for Fertility and Reproductive Medicine, Northwestern University, Chicago, Illinois.

出版信息

Fertil Steril. 2024 Aug;122(2):211-218. doi: 10.1016/j.fertnstert.2024.05.154. Epub 2024 May 27.

Abstract

The objective of this narrative review is to advocate for improved comprehensive care of patients with obesity and infertility. Persons with an increased body mass index have less successful reproductive outcomes, and recently, new medications to treat neuroendocrine hormone imbalances are producing meaningful weight loss akin to surgical interventions. For the first time, obesity is publicly being recognized as a disease. These medications contain the newest generation of glucagon-like peptide 1 receptor agonists and deserve our attention for several reasons: regardless of body mass index, many patients will be using them; it is necessary to understand the mode of action, side effects, and implications for anesthetic procedures and pregnancy; and it is important to evaluate when they could be used to improve health outcomes and/or access to fertility care.

摘要

本综述旨在倡导改善肥胖和不孕患者的综合护理。体重指数增加的患者生殖结局较差,最近,治疗神经内分泌激素失衡的新药物可产生类似手术干预的有意义的体重减轻。肥胖首次被公认为一种疾病。这些药物包含新一代胰高血糖素样肽 1 受体激动剂,值得我们关注,原因有几个:无论体重指数如何,许多患者都将使用这些药物;有必要了解其作用机制、副作用以及对麻醉程序和妊娠的影响;评估它们何时可用于改善健康结果和/或获得生育护理也很重要。

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