在使用奥滨尤妥珠单抗联合苯达莫司汀治疗滤泡性淋巴瘤后，巨细胞病毒感染引发的原发性肾上腺功能不全
Primary Adrenal Insufficiency Triggered by Cytomegalovirus Infection after Obinutuzumab Plus Bendamustine Therapy for Follicular Lymphoma.
作者信息
Nakamura Takashi, Uryu Hideki, Kawashima Ryutaro, Ishiguro Mizuki, Tanizawa Mika, Kanazawa Yasushi, Yamazaki Hiroyuki, Yahagi Yuichi
机构信息
Department of Hematology, Kawaguchi Municipal Medical Center, Japan.
Department of Endocrinology and Diabetes, Kawaguchi Municipal Medical Center, Japan.
出版信息
Intern Med. 2025 Jan 15;64(2):273-279. doi: 10.2169/internalmedicine.3334-23. Epub 2024 May 30.
A 69-year-old man was diagnosed with follicular lymphoma (grade 3A). Obinutuzumab combined with bendamustine (OB) therapy was initiated as salvage chemotherapy. Nausea, abdominal pain, and hyponatremia appeared after six courses of OB therapy; cytomegalovirus (CMV) enteritis with primary adrenal insufficiency (PAI) was a complication. Ganciclovir and hydrocortisone were administered, and the clinical findings improved. PAI caused by CMV infection has mainly been reported in patients with acquired immunodeficiency syndrome. In the present case, the PAI triggered by CMV infection led to immunodeficiency after chemotherapy.
一名69岁男性被诊断为滤泡性淋巴瘤（3A级）。开始使用奥滨尤妥珠单抗联合苯达莫司汀（OB）疗法进行挽救性化疗。在进行六个疗程的OB治疗后出现恶心、腹痛和低钠血症；巨细胞病毒（CMV）肠炎伴原发性肾上腺功能不全（PAI）是一种并发症。给予更昔洛韦和氢化可的松治疗后，临床症状有所改善。CMV感染引起的PAI主要在获得性免疫缺陷综合征患者中报道。在本病例中，CMV感染引发的PAI导致化疗后免疫缺陷。
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