Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, Laboratory of Pharmacology, Araraquara, SP, Brazil. Electronic address: https://twitter.com/gessynger.
Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Curr Opin Neurobiol. 2024 Jun;86:102883. doi: 10.1016/j.conb.2024.102883. Epub 2024 May 29.
The ventral pallidum is a prominent structure within the basal ganglia, regulating reward and motivational processes. Positioned at the interface between motor and limbic structures, its function is crucial to the development and maintenance of substance use disorders. Chronic drug use induces neuroplastic events in this structure, leading to long-term changes in VP neuronal activity and synaptic communication. Moreover, different neuronal populations within the VP drive drug-seeking behavior in opposite directions. This review explores the role of the VP as a hub for reward, motivation, and aversion, establishing it as an important contributor to the pathophysiology of substance use disorders.
腹侧苍白球是基底神经节中的一个突出结构，调节奖励和动机过程。它位于运动和边缘结构的交界处，其功能对于物质使用障碍的发展和维持至关重要。慢性药物使用会在该结构中引起神经可塑性事件，导致 VP 神经元活动和突触通讯的长期变化。此外，VP 内的不同神经元群体以相反的方向驱动觅药行为。本综述探讨了 VP 作为奖励、动机和厌恶的中枢的作用，将其确立为物质使用障碍病理生理学的重要贡献者。
