Baskin D G, Stein L J, Ikeda H, Woods S C, Figlewicz D P, Porte D, Greenwood M R, Dorsa D M
Life Sci. 1985 Feb 18;36(7):627-33. doi: 10.1016/0024-3205(85)90166-3.
The concentration of immunoreactive insulin (IRI) extracted from the olfactory bulb, hypothalamus, hippocampus, cerebral cortex, amygdala, midbrain, and hindbrain was significantly lower in obese (fa/fa) and heterozygous (Fa/fa) Zucker rats in comparison to lean (Fa/Fa) Zucker rats. This deficit in brain IRI content was most severe in the hypothalamus and olfactory bulb and was independent of severe obesity since the marked reduction of brain IRI content was also found in heterozygous rats which possessed only one copy of the fa allele. These results demonstrate that in the 2-3 month-old female Zucker rat, the fa allele is associated with defective regulation of insulin in the brain.
与瘦型（Fa/Fa） Zucker大鼠相比，肥胖型（fa/fa）和杂合型（Fa/fa） Zucker大鼠嗅球、下丘脑、海马体、大脑皮层、杏仁核、中脑和后脑提取的免疫反应性胰岛素（IRI）浓度显著降低。大脑IRI含量的这种不足在下丘脑和嗅球中最为严重，并且与严重肥胖无关，因为在仅拥有一个fa等位基因拷贝的杂合大鼠中也发现了大脑IRI含量的显著降低。这些结果表明，在2至3月龄的雌性Zucker大鼠中，fa等位基因与大脑中胰岛素调节缺陷有关。
