Lee Youngsoo, Lee Sun-Kyung, Park So-Young, Kim Min-Hye, Kang Sung-Yoon, Ban Ga-Young, Nam Young-Hee, Kim Joo-Hee, Rhee Chin Kook, Song Woo-Jung, Kwon Jae-Woo, Lee Taehoon, Kim So Ri, Park Heung-Woo, Cho You Sook, Koh Young-Il, Yoo Kwang-Ha, Lee Byung-Jae, Yoon Ho Joo, Park Hae-Sim, Kim Sang-Heon
Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea.
Department of Mathematics, College of Natural Sciences, Hanyang University, Seoul, South Korea.
World Allergy Organ J. 2024 May 22;17(5):100903. doi: 10.1016/j.waojou.2024.100903. eCollection 2024 May.
Exposure to allergens or irritants in the workplace may affect asthma control and the quality of life (QoL) of patients with asthma.
To examine the prevalence and characteristics of work-related asthma (WRA) in adult patients with severe asthma.
We analyzed data from the Korean Severe Asthma Registry (KoSAR), which is a nationwide multicenter observational study on severe asthma in Korea. Severe asthma was defined according to the American Thoracic Society (ATS) and the European Respiratory Society (ERS) guidelines. WRA was identified on the basis of asthma symptom aggravation at the workplace, as indicated by responses to a structured questionnaire. We compared the demographic and clinical characteristics and QoL between adult patients with severe asthma and WRA and those without WRA.
Among 364 patients with severe asthma who were employed at the time of enrollment, 65 (17.9%) had WRA. There were no significant differences in age, sex, obesity, or smoking history between the WRA and non-WRA groups. However, individuals with WRA exhibited a higher prevalence of anxiety (7.7% vs 2.4%, P = 0.046) and depression (12.3% vs 3.7%, P = 0.010) than those without. The levels of asthma control, lung function, and frequency of asthma exacerbations were similar between the two groups, but patients with WRA reported lower QoL, as determined by the Quality of Life Questionnaire for Adult Korean Asthmatics (56.6 ± 14.6 vs. 63.5 ± 13.9, P < 0.001).
Patients with severe asthma and WRA are more likely to experience anxiety and depression and have lower QoL than those without WRA.
在工作场所接触过敏原或刺激物可能会影响哮喘的控制以及哮喘患者的生活质量（QoL）。
研究成年重症哮喘患者中职业性哮喘（WRA）的患病率及特征。
我们分析了韩国重症哮喘登记处（KoSAR）的数据，该登记处是一项针对韩国重症哮喘的全国性多中心观察性研究。重症哮喘根据美国胸科学会（ATS）和欧洲呼吸学会（ERS）的指南进行定义。根据对一份结构化问卷的回答所表明的工作场所哮喘症状加重情况来确定WRA。我们比较了成年重症哮喘合并WRA患者与不合并WRA患者的人口统计学和临床特征以及生活质量。
在364名入组时就业的重症哮喘患者中，65名（17.9%）患有WRA。WRA组和非WRA组在年龄、性别、肥胖或吸烟史方面无显著差异。然而，与无WRA的个体相比，WRA个体出现焦虑（7.7%对2.4%，P = 0.046）和抑郁（12.3%对3.7%，P = 0.010）的患病率更高。两组之间的哮喘控制水平、肺功能和哮喘加重频率相似，但根据韩国成年哮喘患者生活质量问卷，WRA患者报告的生活质量较低（56.6 ± 14.6对63.5 ± 13.9，P < 0.001）。
与无WRA的患者相比，重症哮喘合并WRA的患者更容易出现焦虑和抑郁，且生活质量更低。
