Mizuno Hiroaki, Nakazawa Hironobu, Miyagawa Akihisa, Yakiyama Yumi, Sakurai Hidehiro, Fukuhara Gaku
Department of Chemistry, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-Ku, Tokyo, 152-8551, Japan.
Division of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka, 565-0871, Japan.
Sci Rep. 2024 May 31;14(1):12534. doi: 10.1038/s41598-024-63304-4.
The synthesis of signal-amplifying chemosensors induced by various triggers is a major challenge for multidisciplinary sciences. In this study, a signal-amplification system that was flexibly manipulated by a dynamic allosteric effector (trigger) was developed. Herein, the focus was on using the behavior of supramolecular polymerization to control the degree of polymerization by changing the concentration of a functional monomer. It was assumed that this control was facilitated by a gradually changing/dynamic allosteric effector. A curved-π buckybowl sumanene and a sumanene-based chemosensor (SC) were employed as the allosteric effector and the molecular binder, respectively. The hetero-supramolecular polymer, (SC·(sumanene)), facilitated the manipulation of the degree of signal-amplification; this was accomplished by changing the sumanene monomer concentration, which resulted in up to a 62.5-fold amplification of a steroid. The current results and the concept proposed herein provide an alternate method to conventional chemosensors and signal-amplification systems.
由各种触发因素诱导的信号放大化学传感器的合成是多学科科学面临的一项重大挑战。在本研究中，开发了一种由动态变构效应物（触发因素）灵活操控的信号放大系统。在此，重点是利用超分子聚合行为，通过改变功能单体的浓度来控制聚合度。据推测，这种控制是由逐渐变化的/动态变构效应物促成的。分别采用弯曲π巴基碗苏曼烯和基于苏曼烯的化学传感器（SC）作为变构效应物和分子粘合剂。杂化超分子聚合物（SC·（苏曼烯））有助于操控信号放大程度；这是通过改变苏曼烯单体浓度实现的，其导致类固醇的放大倍数高达62.5倍。当前的结果以及本文提出的概念为传统化学传感器和信号放大系统提供了一种替代方法。
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