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Essential Tremors: A Literature Review of Current Therapeutics.

作者信息

Patel Maurya D, Patel Muskaan, Jani Rutva, Patel Kishan G, Patel Priyansh, Gandhi Siddharth Kamal

机构信息

Department of Internal Medicine, Smt. Nathiba Hargovandas Lakhmichand (NHL) Municipal Medical College, Ahmedabad, IND.

Department of Internal Medicine, Hinduhridaysamrat Balasaheb Thackeray Medical College (HBTMC) and Dr. Rustom Narsi Cooper Municipal General Hospital, Mumbai, IND.

出版信息

Cureus. 2024 May 1;16(5):e59451. doi: 10.7759/cureus.59451. eCollection 2024 May.


DOI:10.7759/cureus.59451
PMID:38826876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11141324/
Abstract

Essential tremors (ETs) commonly manifest as involuntary shaking of the hands that disrupt daily activities. These tremors involve the central motor network of the cerebellum, thalamus, and cortical networks, leading to different clinical phenotypes. The goal of this review was to establish evidence-based recommendations for effective care and simplify decisions for those dealing with ET. For this narrative literature review, we conducted a thorough search using core keywords such as "essential tremor" and "therapy." From the 27 selected articles, relevant data were presented regarding pathophysiology, medications, and other treatment options, with necessary supplemental data such as side effects and use cases. This paper examines treatments for ET, including commonly prescribed medications such as propranolol and primidone; invasive treatments such as deep brain stimulation, focused ultrasound thalamotomy, transcranial magnetic stimulation, and some surgical methods; and non-invasive methods such as the neuromodulation technique of transcutaneous afferent patterned stimulation. Overall, this study presents a synthesized understanding of the currently available modalities for managing ETs. It is intended to guide care providers in choosing the best possible method to contain symptoms.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/296a/11141324/b47ec573a384/cureus-0016-00000059451-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/296a/11141324/b87b023e70ea/cureus-0016-00000059451-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/296a/11141324/b47ec573a384/cureus-0016-00000059451-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/296a/11141324/b87b023e70ea/cureus-0016-00000059451-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/296a/11141324/b47ec573a384/cureus-0016-00000059451-i02.jpg

相似文献

[1]
Essential Tremors: A Literature Review of Current Therapeutics.

Cureus. 2024-5-1

[2]
Benefits and risks of pharmacological treatments for essential tremor.

Drug Saf. 2003

[3]
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[4]
Managing Essential Tremor.

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[5]
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[6]
MDS evidence-based review of treatments for essential tremor.

Mov Disord. 2019-5-2

[7]
Altered Thalamic Connectivity Due to Focused Ultrasound Thalamotomy in Patients with Essential Tremor.

World Neurosurg. 2022-8

[8]
Differences in intrinsic functional networks in patients with essential tremor who had good and poor long-term responses after thalamotomy performed using MR-guided ultrasound.

J Neurosurg. 2022-7-22

[9]
Pretherapeutic resting-state fMRI profiles are associated with MR signature volumes after stereotactic radiosurgical thalamotomy for essential tremor.

J Neurosurg. 2018-12-1

[10]
Magnetic resonance-guided focused ultrasound thalamotomy restored distinctive resting-state networks in patients with essential tremor.

J Neurosurg. 2022-7-8

本文引用的文献

[1]
Trial of Botulinum Toxin for Isolated or Essential Head Tremor.

N Engl J Med. 2023-11-9

[2]
Comparative Effectiveness of Transcutaneous Afferent Patterned Stimulation Therapy for Essential Tremor: A Randomized Pragmatic Clinical Trial.

Tremor Other Hyperkinet Mov (N Y). 2023

[3]
Cerebellar repetitive transcranial magnetic stimulation versus propranolol for essential tremor.

Brain Behav. 2023-3

[4]
The Hidden Burden of Disease and Treatment Experiences of Patients with Essential Tremor: A Retrospective Claims Data Analysis.

Adv Ther. 2022-12

[5]
Botulinum Toxin for Essential Tremor and Hands Tremor in the Neurological Diseases: A Meta-Analysis of Randomized Controlled Trials.

Toxins (Basel). 2022-3-10

[6]
Deep Brain Stimulation for Arm Tremor: A Randomized Trial Comparing Two Targets.

Ann Neurol. 2022-5

[7]
The Pathophysiology and Treatment of Essential Tremor: The Role of Adenosine and Dopamine Receptors in Animal Models.

Biomolecules. 2021-12-2

[8]
Imaging the Pathophysiology of Essential Tremor-A Systematic Review.

Front Neurol. 2021-6-16

[9]
Tolerability and Efficacy of Customized IncobotulinumtoxinA Injections for Essential Tremor: A Randomized, Double-Blind, Placebo-Controlled Study.

Toxins (Basel). 2020-12-20

[10]
Managing Essential Tremor.

Neurotherapeutics. 2020-10

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