Pupil Research Group at the Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany.
University Eye Hospital, Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany.
Invest Ophthalmol Vis Sci. 2024 Jun 3;65(6):3. doi: 10.1167/iovs.65.6.3.
Investigating influencing factors on the pupillary light response (PLR) as a biomarker for local retinal function by providing epidemiological data of a large normative collective and to establish a normative database for the evaluation of chromatic pupil campimetry (CPC).
Demographic and ophthalmologic characteristics were captured and PLR parameters of 150 healthy participants (94 women) aged 18 to 79 years (median = 46 years) were measured with L-cone- and rod-favoring CPC protocols. Linear-mixed effects models were performed to determine factors influencing the PLR and optical coherence tomography (OCT) data were correlated with the pupillary function volume.
Relative maximal constriction amplitude (relMCA) and latency under L-cone- and rod-favoring stimulation were statistically significantly affected by the stimulus eccentricity (P < 0.0001, respectively). Iris color and gender did not affect relMCA or latency significantly; visual hemifield, season, and daytime showed only minor influence under few stimulus conditions. Age had a statistically significant effect on latency under rod-specific stimulation with a latency prolongation ≥60 years. Under photopic and scotopic conditions, baseline pupil diameter declined significantly with increasing age (P < 0.0001, respectively). Pupillary function volume and OCT data were not correlated relevantly.
Stimulus eccentricity had the most relevant impact on relMCA and latency of the PLR during L-cone- and rod-favoring stimulation. Latency is prolonged ≥60 years under scotopic conditions. Considering the large study collective, a representative normative database for relMCA and latency as valid readout parameters for L-cone- and rod-favoring stimulation could be established. This further validates the usability of the PLR in CPC as a biomarker for local retinal function.
通过提供大型规范群体的流行病学数据，研究瞳孔光反应（PLR）的影响因素，作为局部视网膜功能的生物标志物，并建立用于评估色光瞳孔量计（CPC）的规范数据库。
记录人口统计学和眼科特征，并使用 L-锥体和棒状优势 CPC 方案测量 150 名 18 至 79 岁（中位数=46 岁）健康参与者的 PLR 参数。进行线性混合效应模型以确定影响 PLR 的因素，并将光学相干断层扫描（OCT）数据与瞳孔功能体积相关联。
L-锥体和棒状优势刺激下的相对最大收缩幅度（relMCA）和潜伏期受到刺激偏心度的显著影响（分别为 P<0.0001）。虹膜颜色和性别对 relMCA 或潜伏期没有显著影响；在少数刺激条件下，视觉半视野、季节和白天仅显示较小的影响。在棒状特异性刺激下，年龄对潜伏期有统计学显著影响，潜伏期延长≥60 年。在明视和暗视条件下，基础瞳孔直径随年龄增加而显著减小（分别为 P<0.0001）。瞳孔功能体积和 OCT 数据没有相关关系。
在 L-锥体和棒状优势刺激下，刺激偏心度对 relMCA 和 PLR 潜伏期的影响最大。在暗视条件下，潜伏期延长≥60 年。考虑到大型研究群体，可以为 relMCA 和潜伏期建立代表规范数据库，作为 L-锥体和棒状优势刺激的有效读出参数。这进一步验证了 CPC 中 PLR 作为局部视网膜功能生物标志物的可用性。
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