Cardiology Department, Regional General Hospital 'F. Miulli', Acquaviva delle Fonti, Italy.
Scientific Clinical Institutes Maugeri, Institutes of Care and Research, Institute of Bari, Bari.
J Cardiovasc Med (Hagerstown). 2024 Jul 1;25(7):511-518. doi: 10.2459/JCM.0000000000001632. Epub 2024 May 14.
The identification of patients at greater mortality risk of death at admission into an intensive cardiovascular care unit (ICCU) has relevant consequences for clinical decision-making. We described patient characteristics at admission into an ICCU by predicted mortality risk assessed with noncardiac intensive care unit (ICU) and evaluated their performance in predicting patient outcomes.
A total of 202 consecutive patients (130 men, 75 ± 12 years) were admitted into our tertiary-care ICCU in a 20-week period. We evaluated, on the first 24 h data, in-hospital mortality risk according to Acute Physiology and Chronic Health Evaluation II (APACHE II) and Simplified Acute Physiology Score 3 (SAPS 3); Sepsis related Organ Failure Assessment (SOFA) Score and the Mayo Cardiac intensive care unit Admission Risk Score (M-CARS) were also calculated.
Predicted mortality was significantly lower than observed (5% during ICCU and 7% at discharge) for APACHE II and SAPS 3 (17% for both scores). Mortality risk was associated with older age, more frequent comorbidities, severe clinical presentation and complications. The APACHE II, SAPS 3, SOFA and M-CARS had good discriminative ability in distinguishing deaths and survivors with poor calibration of risk scores predicting mortality.
In a recent contemporary cohort of patients admitted into the ICCU for a variety of acute and critical cardiovascular conditions, scoring systems used in general ICU had good discrimination for patients' clinical severity and mortality. Available scores preserve powerful discrimination but the overestimation of mortality suggests the importance of specific tailored scores to improve risk assessment of patients admitted into ICCUs.
识别入住重症心血管监护病房(ICCU)时死亡率较高的患者对临床决策具有重要意义。我们通过非心脏重症监护病房(ICU)评估的预测死亡率来描述入住 ICU 时患者的特征,并评估其预测患者结局的性能。
在 20 周内,我们共收治了 202 例连续患者(男性 130 例,75±12 岁)到我们的三级护理 ICCU。我们在入院的前 24 小时数据中评估了住院死亡率,评估指标为急性生理学和慢性健康评估 II(APACHE II)和简化急性生理学评分 3(SAPS 3);还计算了脓毒症相关器官衰竭评估(SOFA)评分和梅奥心脏重症监护病房入院风险评分(M-CARS)。
APACHE II 和 SAPS 3 的预测死亡率明显低于观察死亡率(ICCU 期间为 5%,出院时为 7%)(两个评分的死亡率均为 17%)。死亡率风险与年龄较大、合并症更频繁、严重的临床表现和并发症相关。APACHE II、SAPS 3、SOFA 和 M-CARS 在区分死亡和存活患者方面具有良好的鉴别能力,但风险评分预测死亡率的校准效果较差。
在最近的一组因各种急性和危急心血管疾病入住 ICCU 的患者中,一般 ICU 使用的评分系统对患者的临床严重程度和死亡率具有良好的区分能力。现有的评分具有强大的区分能力,但对死亡率的高估表明,需要特定的定制评分来提高对入住 ICCU 的患者的风险评估。