An Update on the Genetic Drivers of Corticotroph Tumorigenesis.

The genetic landscape of corticotroph tumours of the pituitary gland has dramatically changed over the last 10 years. Somatic changes in the gene account for the most common genetic defect in corticotrophinomas, especially in females, while variants in or are associated with a subset of aggressive tumours. Germline defects have also been identified in patients with Cushing's disease: some are well-established (), while others are rare and could represent coincidences. In this review, we summarise the current knowledge on the genetic drivers of corticotroph tumorigenesis, their molecular consequences, and their impact on the clinical presentation and prognosis.