From the Department of Pathology, Faculty of Medicine, King Abdulaziz University and King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia.
Saudi Med J. 2024 Jun;45(6):560-564. doi: 10.15537/smj.2024.45.6.20230962.
To analyze the immunohistochemical staining pattern of mismatch repair (MMR) proteins and p53 in endometrial carcinoma cases, including different subtypes and stages, to gain insights into their role in the pathogenesis and clinical behaviour of this malignancy.
In this study, we investigate the association between MMR deficiency, p53 mutational status, and clinical outcomes in various subtypes of endometrial carcinoma. The immunohistochemical staining pattern of MMR proteins in 96 cases of endometrial carcinoma have been analyzed, including 72 endometrioid, 14 papillary serous, 5 clear cell, and 5 mixed Müllerian tumor.
The results showed that 36 cases were MMR deficient, with the majority being of endometrioid subtype. The p53 immunostain showed a mutational pattern in a subset of cases, with a documented dismal prognosis. However, aforementioned stains failed to predict synchronous or metachronous cancers in 5 patients.
These findings highlight the importance of MMR and p53 immunohistochemical staining in the classification, and prognosis of endometrial carcinoma.
分析错配修复（MMR）蛋白和 p53 在子宫内膜癌病例中的免疫组织化学染色模式，包括不同的亚型和分期，以深入了解它们在这种恶性肿瘤的发病机制和临床行为中的作用。
在这项研究中，我们研究了 MMR 缺陷、p53 突变状态与各种子宫内膜癌亚型之间的关系。我们分析了 96 例子宫内膜癌中 MMR 蛋白的免疫组织化学染色模式，包括 72 例子宫内膜样癌、14 例乳头状浆液性癌、5 例透明细胞癌和 5 例混合性 Müller 瘤。
结果显示，36 例 MMR 缺陷，其中大多数为子宫内膜样亚型。p53 免疫组化显示部分病例存在突变模式，预后不良。然而，上述染色未能预测 5 例患者的同步或异时性癌症。
这些发现强调了 MMR 和 p53 免疫组织化学染色在子宫内膜癌的分类和预后中的重要性。
