Rodríguez Hernández Cristina, Medrano Espinosa Omar, Sampieri-Cabrera Raúl, Oviedo Lara Alan R
Psychiatry, Rome Psiquiatría Integral, Mexico City, MEX.
Department of Physiology, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, MEX.
Cureus. 2024 May 3;16(5):e59612. doi: 10.7759/cureus.59612. eCollection 2024 May.
Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique that induces action potentials in the stimulated cortical area and has been approved by the Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD). The prevalence of MDD in Mexico almost tripled after the COVID-19 pandemic. In this study, we evaluated the safety and therapeutic effects of low-intensity TMS (Li-TMS) - characterized by inducing electric currents below the action potential threshold on the cerebral cortex - in 41 subjects diagnosed with treatment-resistant depression (TRD). A Li-TMS device dispensed repetitive magnetic pulses at 30 mT for 60 minutes during 20 sessions (once daily from Monday to Saturday) with the theta burst pattern. Our results suggest that Li-TMS is a safe therapy with antidepressant effects, demonstrated by the decrease in Beck Depression Inventory (BDI) scores and lessening of depressive symptoms.
经颅磁刺激（TMS）是一种非侵入性神经调节技术，可在受刺激的皮质区域诱发动作电位，并且已获得美国食品药品监督管理局（FDA）批准用于治疗重度抑郁症（MDD）。在2019冠状病毒病大流行后，墨西哥MDD的患病率几乎增加了两倍。在本研究中，我们评估了低强度TMS（Li-TMS）——其特点是在大脑皮层诱发低于动作电位阈值的电流——对41名诊断为难治性抑郁症（TRD）患者的安全性和治疗效果。一台Li-TMS设备以θ爆发模式在20次治疗期间（从周一至周六每天一次），以30 mT的强度发放重复磁脉冲，持续60分钟。我们的结果表明，Li-TMS是一种具有抗抑郁作用的安全疗法，贝克抑郁量表（BDI）评分降低和抑郁症状减轻证明了这一点。
