2007年至2019年埃及达米埃塔病毒性与非病毒性病因肝细胞癌的临床表现、治疗及生存情况比较
A Comparison of Presentation, Treatment, and Survival After Hepatocellular Carcinoma of Viral and Non-Viral Etiology in Damietta, Egypt, 2007-2019.
作者信息
Jean Kévin, Tawheed Ahmed, Luong Nguyen Liem Binh, Heikal Tarek, Eldaly Usama, Gaber Elhadidy Neveen, Elghaieb Ahmed, Aboudonia Ahmed, Tondeur Laura, Dublineau Amélie, Fontanet Arnaud, El-Kassas Mohamed
机构信息
Laboratoire MESuRS, Conservatoire national des arts et métiers, Paris, France.
Unité PACRI, Institut Pasteur & Conservatoire national des arts et métiers, Paris, France.
出版信息
J Hepatocell Carcinoma. 2024 May 31;11:997-1004. doi: 10.2147/JHC.S455832. eCollection 2024.
CONTEXT
The difference in prognosis between patients diagnosed with viral versus non-viral hepatocellular carcinoma (HCC) in Egypt remains unclear.
METHODS
We used data from patients diagnosed with HCC between 2007 and 2019 from a large monocentric retrospective cohort at the Damietta Oncology referral center (northern Egypt). Presentation and treatment were compared between viral versus non-viral etiology HCC patients. Survival was compared relying on univariate and multivariate Cox regressions.
RESULTS
Data from 4714 HCC patients were analyzed. Among them, 204 (4.3%) presented with a non-viral etiology. Patients with non-viral versus viral etiology had a similar presentation overall, especially regarding the BCLC stage at HCC diagnosis. After controlling for various individual characteristics, patients with non-viral versus viral etiology had poorer survival (adjusted Hazard Ratio: 1.244; 95% Confidence Interval: 1.069-1.447).
CONCLUSION
Despite similar features, patients with non-viral- related HCC had poorer survival compared to patients with viral-related HCC.
背景
在埃及，病毒相关性肝细胞癌（HCC）与非病毒相关性肝细胞癌患者的预后差异仍不明确。
方法
我们使用了来自达米埃塔肿瘤转诊中心（埃及北部）一个大型单中心回顾性队列中2007年至2019年间被诊断为HCC的患者的数据。比较了病毒病因与非病毒病因HCC患者的临床表现和治疗情况。依靠单因素和多因素Cox回归比较生存率。
结果
分析了4714例HCC患者的数据。其中，204例（4.3%）病因是非病毒的。非病毒病因与病毒病因的患者总体临床表现相似，尤其是在HCC诊断时的BCLC分期方面。在控制了各种个体特征后，非病毒病因与病毒病因的患者生存率较低（调整后风险比：1.244；95%置信区间：1.069 - 1.447）。
结论
尽管特征相似，但与病毒相关性HCC患者相比，非病毒相关性HCC患者的生存率较低。
Zotero 插件